Nucleus and does not replicate however there is

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nucleus and does not replicate • However there is evidence that HIV provirus can begin producing new copies of HIV RNA immediately after becoming a provirus or shortly thereafter • Mistake in book, p.339, glossary lysogeny: the phenomenon in which a virus remains in the cell cytoplasm as a fragment of DNA and fails to replicate in or destroy the cell. nucleus
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20 HIV in Lysogenic cycle = latent infection HIV DNA is integrated into the host cell’s chromosome as provirus Patient does not have AIDS, but has HIV infection Is in good health but is infectious !!! The provirus can be transmitted via infected T cells in blood and semen
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21 Targets for inhibiting HIV replication Block entry of HIV into host cell by blocking CD4 &/or coreceptors • Inhibit reverse transcriptase because only HIV has this enzyme • Inhibit integrase so HIV cannot integrate • Inhibit protease so HIV cannot process its proteins into functional subunits
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22 Movie of targeting HIV replication http://www.youtube.com/watch?v=RO8MP3wMvqg
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23 Apoptosis
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24 Apoptosis • Apoptosis is programmed cell death • Apoptosis is the natural mechanism that the body uses to get rid of “old” cells • HIV infection speeds up apoptosis of CD4 T lymphocytes; loss of significant numbers of T cells leaves body susceptible to opportunistic infections
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25 Apoptosis movie http://www.youtube.com/watch?v=V-NsR-krKME&feature=related
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26 Syncytia Formation Nucleus
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27 HIV Genome and Genes Capsid Integrase Protease gp120 gp41
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28 HIV Genome and Proteins gag pol env
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