Figure 17.7 on page 638 in the textbook reviews the life cycle of RBC’sRed blood cells (erythrocytes) are biconcave disks and this shape increases the __ _Count of the cell and maximizes diffusion of gases. Watch the hemoglobin animation in the course documents. What is hypoxia? What is cyanosis?

What is a typical RBC count for males? What is a typical RBC count for females? 4.2 to 5.4 million/mmcubed RBC Production: After birth, RBC production occurs in the red _ bone marrow _. The average life span of a red blood cell is ___ 100-120 days ________. Control of RBC production: Hormonal Control: The total number of red blood cells remains relatively constant due to a _ negative __ feedback mechanism utilizing the hormone __ erythropoietin __that is released from the kidneys and liver in response to the detection of low __ oxygen ___ levels Dietary Factors Affecting Red Blood Cell Production: Vitamins __ B12 ___ and __ Folic _____ acid are needed for DNA synthesis, so they are necessary for the reproduction of all body cells, especially in hematopoietic tissue. The mineral __ iron ___ is also needed for hemoglobin synthesis. Destruction of Red Blood Cells With age, red blood cells become increasingly fragile and are damaged by passing through __ capillaries _____. Macrophages in the __ liver ___ and ___ spleen ___ phagocytize damaged red blood cells. Hemoglobin from the decomposed red blood cells is converted into __ heme ____ and _____ globin ___________. What happens to the heme and iron? How is physiologic jaundice in newborns related to the destruction of heme? How is it treated?