2019 Anemia Retrieved from Hammer G D

2019 anemia retrieved from hammer g d

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American Society of Hematology. (2019). Anemia Retrieved from; Hammer, G. D., & McPhee, S. J. (2019). Pathophysiology of disease: An introduction to clinical medicine (8th ed.). New York, NY: McGraw-Hill Education. Huether, S. E., & McCance, K. L. (2017). Understanding pathophysiology (6th ed.). St. Louis, MO: Mosby Amy, Sideroblastic anemia (SA) is a blood disordered identified by the impaired ability of the bone marrow to produce healthy red blood cells. As a result, iron accumulates in the red blood cells giving a ringed appearance to the nucleus (U. S. Department of Health& Human Services, 2017). Hereditary (congenital) form of SA is a defect in the X-link recessive gene (ALAS2). This enzyme is critical for the production of heme, the oxygen-carrying portion of the hemoglobin. Acquired SA is due to prolonged exposure to drugs/toxins or immune disorders, granulomatous disease, tumors, or metabolic disorders (National Organization for Rare Disease, n.d.). Due to the similarities in clinical symptoms, SA can be mistaken for iron deficiency anemia. A bone marrow biopsy is the only way to diagnose SA officially. As an advanced practice nurse is essential to differentiate the two disorders because both require treating the underlying causes. However, depending on the severity, SA also requires pyridoxine therapy, iron depletion therapy, transfusion, and chelation therapy as well (Huether & McCance, 2017). Huether, S. E., & McCance, K. L. (2012). Understanding pathophysiology (6 th ed.). St. Louis, MO: Mosby.
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National Organization for Rare Disease. (n.d.). Sideroblastic a nemia. Retrieved from; U.S. Department of Health & Human Services. (2017). Sideroblastic anemia. Retrieved from;
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