Dietary Supplements Fall 2012

Allergic reactions anaphylaxis urticaria may increase

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Allergic reactions: anaphylaxis, urticaria May increase risk of bleeding in patients  taking anticoagulant or antiplatelet therapy Garlic
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Plant:   Hypericum perforatum Extract from buds and leaves Proposed uses: Depression (mild-moderate ) Anxiety Obsessive compulsive disorder Mood changes a/w premenstrual  syndrome and menopause Dose: 300mg PO TID St. John’s Wort http://z.about.com/d/altmedicine/1/0/D/7/73072866.jpg  
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Efficacy: Results vary significantly: Less than or as effective as traditional antidepressants Self treatment of depression is NOT recommended Safety profile: Common: GI upset, insomnia/restlessness, dry mouth Others: agitation/irritability, mania, photosensitivity, skin rash,  dizziness Drug-interactions Potent CYP-3A4 inducer: OCPs, anti-epileptics, protease inhibitors  (HIV) Antidepressants Caution: bipolar, schizophrenia St. John’s Wort
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Plant:   Serenoa repens Extract from the ripened fruit Proposed uses: Benign prostatic hyperplasia (BPH) Dose: 320 mg once daily or  in divided doses 80-95% fatty acids Saw Palmetto http://www.nbbd.com/godo/cns/Brochures/vistas/SawPalmetto.jpg  
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Efficacy: Mild-moderate BPH symptoms:  Improvement in urinary symptoms Moderate-severe BPH symptoms: Similar to placebo Long term data is lacking Safety profile: Usually well tolerated Diarrhea at high doses Avoid use in pregnancy/lactation Inhibits 5 -reductase α Saw Palmetto
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Omega-3 fatty acids: Naturally found in salmon, sardines, trout, tuna Essential fatty acids Docosahexaenoic acid (DHA) Eicosapentaenoic acid (EPA) Proposed uses: Dyslipidemia Hypertension Heart disease Inflammatory conditions: Psoriasis Rheumatoid arthritis Dose: 1-4 grams daily Fish Oil
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Efficacy: Dyslipidemia: 25-30%  in triglycerides Small   in LDL and HDL Prevention of CHD: Both retro- and prospective studies have shown benefit Inflammation: Decreases pain and swelling Safety profile: GI (dose-related):intolerance, fishy aftertaste/halitosis,  belching  May increase risk of bleeding in patients  taking anticoagulant or antiplatelet therapy Fish Oil
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Glucosamine: Derived from shellfish exoskeletons or synthetically made Chondroitin: Synthetically made from animal cartilage Proposed uses: Osteoarthritis Improved cartilage synthesis Dose:  Combination product: 3-4 tablets per day Glucosamine/chondroitin
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Efficacy: Shown to reduce pain and joint stiffness Modest pain relief over placebo Safety profile: GI: nausea, stomach upset, constipation, diarrhea Take with food Allergic skin reactions
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  • Fall '12
  • lipsh
  • safety profile, health care providers., Providers. Consumer Survey, Consumer Survey Report, Care Providers. Consumer

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