Lecture 17 -Receptors G-proteins

Signal transduction molecular switches membrane

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Signal Transduction Molecular Switches Membrane embedded receptor Proteins transmit information into the cell The Ras protein, like the G subunit of heterotrimeric G proteins, cycles between an inactive GDP-bound form and active form bound to GTP Tyrosine kinase modules of some receptors upon dimerization are activated by cross- phosphorylation. Phosphorylated tyrosines serve as docking sites for adaptor and signaling proteins which permit further propagation of the signal. Net result is amplification, fidelity and diversity
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G-protein and receptor tyrosine kinase signalling pathways
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Growth Hormone
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Signal Transduction Molecular Switches Membrane embedded receptor Proteins transmit information into the cell The Ras protein, like the G subunit of heterotrimeric G proteins, cycles between an inactive GDP-bound form and active form bound to GTP Tyrosine kinase modules of some receptors upon dimerization are activated by cross- phosphorylation. Phosphorylated tyrosines serve as docking sites for adaptor and signaling proteins which permit further propagation of the signal. Net result is amplification, fidelity and diversity
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