Lecture 17 -Receptors G-proteins

– to dampen the sensitivity phosducin reduces

Info iconThis preview shows pages 37–61. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: – To dampen the sensitivity, phosducin reduces transducin’s activity • Binds G and pulls it into the cytoplasm where it is inactive Structure of phodsucin Phosducin blocks G binding site of G phosducin G Phosducin binding is negatively regulated by phosphorylation of Serine 73 How Ras gets activated Signal Transduction Molecular Switches • Membrane embedded receptor Proteins transmit information into the cell • The Ras protein, like the G subunit of heterotrimeric G proteins, cycles between an inactive GDP-bound form and active form bound to GTP • Tyrosine kinase modules of some receptors upon dimerization are activated by cross- phosphorylation. Phosphorylated tyrosines serve as docking sites for adaptor and signaling proteins which permit further propagation of the signal. • Net result is amplification, fidelity and diversity G-protein and receptor tyrosine kinase signalling pathways Growth Hormone Signal Transduction Molecular Switches • Membrane embedded receptor Proteins transmit information into the cell • The Ras protein, like the G subunit of heterotrimeric G proteins, cycles between an inactive GDP-bound form and active form bound to GTP • Tyrosine kinase modules of some receptors upon dimerization are activated by cross- phosphorylation. Phosphorylated tyrosines serve as docking sites for adaptor and signaling proteins which permit further propagation of the signal. • Net result is amplification, fidelity and diversity...
View Full Document

{[ snackBarMessage ]}

Page37 / 61

– To dampen the sensitivity phosducin reduces...

This preview shows document pages 37 - 61. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online