Cost reduction the current high cost of drug

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Cost Reduction The current high cost of drug discovery and development is a major cause for concern among pharmaceutical companies [13]. Along with increasing productivity, pharmaceutical companies also aim to reduce the high failure rate in the drug discovery process so that increased number of drugs able to hit the market [14]. The high cost of various phases of clinical trials acts as limiting factors for number of drugs, which can be developed by pharmaceutical companies, and hence selecting the compounds with the best chances for approval is critical [15]. The costs of drug discovery and development generally include total costs from discovery to approval though some studies have included the costs of failed drugs and the costs for commercialization [13,16]. There is also a cost associated with the elongated process, beginning from discovery all the way to final approval [15,17]. Advances in bioinformatics accelerate drug discovery process, beginning with drug target identification and validation (viz., Docking), to assay development, and virtual-high-throughput screening (v- HTS)-all with the goal of identifying new potential chemical entities. Bioinformatics provides more efficient target discovery and validation approaches, thus help to ensure that more drug candidates are successful during the approval process and making it more cost-effective [3].
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Open Access Journal of Pharmaceutical Research Reddy MA. Bioinformatics-Key to Drug Discovery and Development. J Pharm Res 2017, 1(5): 000126. Copyright© Reddy MA. 3 Figure 1: The role of bioinformatics in different stages of drug discovery process. Promote Novel Drug Development There are some collateral costs that bother the pharmaceutical industry [18]. These costs include commercialization costs, litigation and drug-recall costs, and general costs to society [17,19,20]. Commercialization costs for new drug to be about $250 million per approved drugs, are high mainly because most ‘‘new’’ drugs approved are essentially functional replicas of drugs that already exist [16,21]. Most of the copycat drugs are being commercialized to handle the illness for which there are drugs already; thus, there is a need of interface that can attract the attention of both physicians and patients who already have access to similar medication [22]. Bioinformatics can act as proper interface, and provides new approaches and opportunities to pharmaceutical companies to efficiently discover potential drug targets and develop novel drugs [2]. If drugs are not commercialized in competition with already existing equivalents, their commercialization costs are expected to fall significantly [23]. Barriers to Bioinformatics Progress in Drug Design Process Bioinformatics efforts did not make any impeccable changes in the drug discovery and development process.
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