Immunology Lecture Exam 3 - Study Guide Chapter 5 & 6 - Kara.docx

Delta chain situated with alpha chain locus on

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Delta chain situated with Alpha chain locus on Chromosome 14; Gamma gene on Chromosome 7; gamma resembles alpha, delta resembles beta; between V-alpha/ J- alpha 10. What is unique about gamma/delta T-cells. a. No MHC required to present peptide; Doesn’t need antigen presented to it compensates for lack of diversity by adding an extra D segment to increase junctional diversity 11. MHC class I molecules and MHC class II molecules, what do they do? What do they activate? Which cells can present with these? Knight Essentials
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Kara Kohlmaier a. MHC1= Bind to intracellular pathogenic peptides, present to CD8 cytotoxic T cells. All nucleated cells can present with these b. MHC2= Bind to extracellular pathogenic peptides, present to CD4 T helper cells, activate macrophages (TH1) and B cells (TH2). Cells that can be present w/ MHC II include dendritic cells, macrophages, B cells, pathogens 12. Structure of MHC class I and class II molecules; b2- microglobulin: a. MHC1= has a transmembrane heavy chain, or alpha chain that is complexed to a beta microglobulin; alpha chain is broken up into three parts (alpha 1, alpha 2, alpha 3) b. MHC2= has two chains, an alpha and beta chain, encoded by MHC genes, both broken up into two parts (alpha1, 2 beta 1, 2) 13. Peptide (length) that can bind in MHC class I and MHC class II molecules: a. MHC1 = 8-10 b. MHC2 = 13-25 14. Peptide binding groove of MHC class I and MHC class II molecule: a. MHC I= the peptide is grasped by pockets at either end of the peptide binding groove. b. MHC II= can hold longer peptides because it doesn't pin the peptides down, extend out at each end of groove 15. What does the degenerate/promiscuous binding of MHC molecules allow? a. It allows MHC molecules to bind to a variety of different peptide sequences without having to mutate or change 16. Which class of T cells will be activated for intracellular vs. extracellular pathogens: a. CD8 for intracellular pathogens CD4 for extracellular pathogens 17. Class of MHC molecules will be utilized for intracellular vs. extracellular pathogens: a. MHC1= intracellular, take place in ER( calnexin, calreticulin, tapsin, TAP, proteasome) b. MHC2= extracellular, take place in endocytic vesicle(invariant chain, CLIP, HLA- DM) Knight Essentials
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Kara Kohlmaier 18. Cytotoxic T cells and co-receptor CD8, do these stay in the secondary lymphoid tissue after activation of go to the site of infection? a. Goes to site of infection, won't find many infected cells in the lymph 19. Process for generating peptides from intracellular vs. extracellular pathogens (video) 20. Proteasome; TAP-1 and TAP-2; Calnexin; Invariant chain; HLA-DM; CLIP; Chaperones molecules: a. Proteasome= breaks down proteins into peptides b. TAP-1/TAP-2= allow peptides to enter the ER. Dependent on binding and hydrolysis of ATP c. Calnexin= helps fold MHC I/ binds to MHC Class I heavy chain to retain folded form until support of β2-Microglobulin d. Invariant Chain= moves MHC II from ER to Cytosol, Prevents unwanted peptides from binding (identical from person to person) HLA-DM= MHC II like, removes
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  • Winter '17
  • GREGORYWEIGEL
  • T Cell, Major histocompatibility complex, B cell, Kara Kohlmaier

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