bones and other tissues. If the pituitary gland makes too much growth hormone, excessive amounts of IGF-I can result. Too much IGF-I can cause abnormal growth of the soft tissues and skeleton and other signs and symptoms characteristic of acromegaly and gigantism. In adults, a tumor is the most common cause of too much growth hormone production. Pituitary tumors are in most cases of acromegaly are caused by a noncancerous tumor of the pituitary gland. The tumor secretes excessive amounts of growth hormone, causing many of the signs and symptoms of acromegaly. Some of the symptoms of acromegaly, such as headaches and impaired vision, are due to the tumor mass pressing on nearby brain tissues. Non-pituitary tumors happen in a few people with acromegaly, tumors in other parts of the body, such as the lungs, pancreas or adrenal glands, cause the disorder. Sometimes, these tumors actually secrete growth hormone. In other cases, the tumors produce a hormone called growth hormone-releasing hormone (GH-RH), which stimulates the pituitary to make extra growth hormone.
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- Fall '14