Anxiety Paroxetine Escitalopram venlafaxine duloxetine Buspirone BDZ

Anxiety paroxetine escitalopram venlafaxine

This preview shows page 3 - 6 out of 13 pages.

Anxiety Paroxetine, Escitalopram, venlafaxine, duloxetine, Buspirone, BDZ,, hydroxyzine, pregabalin PTSD SSRIs (sertraline & paroxetine), fluoxetine OCD TCA (Clomipramine), SSRIs (Fluvoxamine, Fluoxetine, sertraline, paroxetine), Fluoxetine, sertraline in children Panic Attack Escitalopram, fluoxetine, sertraline, paroxetine, venlafaxine, clonazepam,
Image of page 3
alprazolam Antidepressants & Antianxiety Nonselective norepinephrine- serotonin reuptake inhibitors (tricyclic & heterocyclic) Monoamine oxidase inhibitors (MAOIs) Serotonin-selective reuptake inhibitors (SSRIs) MOA Inhibit the reuptake of NE and 5HT while also blocking serotonergic, α-adrenergic, histaminic, and muscarinic receptors Inhibit monoamine oxidase terminating the actions of neurotransmitters such as dopamine, NE, epinephrine, and serotonin. Affect serotonin neurotransmitter in synaptic cleft by blocking serotonin transporter from returning serotonin to presynaptic cell Amitriptyline , Nortriptyline, imipramine, Doxepin, Trimipramine maleate, Amoxapine, Desipramine, Protriptyline HCL, clomipramine Phenelzine (Nardil), Isocarboxazid (Marplan), Tranylcypromine (Parnate), Selegiline (Emsam)- Parkinson’s dz Fluoxetine (Prozac), Paroxetine (Paxil) Sertraline (Zoloft) Fluvoxamine (Luvox) Citalopram (Celexa) Escitalopram (Lexapro) Vortioxetine (Brintellix), Pharmaco -kinetics Have fairly long half-life of 6 to 18 hours; Liver metabolism strong CYP 2D6 Not the first line drug pregnancy C Major liver metabolism and half-life within 1-3 hours Not the first line drug Pregnancy C Frist-pass effect in liver via CYP450 & excreted in kidney Half-life: 26 hr The most common & initial drug choice Paroxetine-pregnancy D; Fluvoxamine & vortioxetine— C; others-B Pharmaco - therapeut ics Contraindication in CVD ; lower Sz threshold, cautious use in the elderly; anticholinergic effect Indication for depression, pain disorder, enuresis, neuropathic pain Contraindication in liver, kidney dz, CHF, Arteriosclerotic dz, >60 yr old Hypertensive crisis when using other antidepressant, sympathomimetics, foods containing tyramine —treated with phentolamine (Regitine) 14-day restriction on initiating SRIs or SNRIs Tx to prevent serotonin syndrome Contraindication in hypersensitivity, concurrent or within 14 days of MAOIs Indication Tx of depression, anxiety, panic disorder; OCD; bulimia except Fluvoxamine-OCD Fluoxetine—effective in MDD (major depression disorder) for children 8- 17 yr; OCD in children 7-17 yr old Escitalopram-effective in MDD for adolescent age 12-17 Increase risk of suicide within the first 3 wks of taking SSRI and other antidepressant Lab monitoring not needed when pt on SSRIs ADRs Increase risk of cardiotoxicity Dizziness, HA, Insomnia, CNS, GI, sexual dysfunction Serotonin Syndrome;
Image of page 4
hypotension, diarrhea fluoxetine, sertraline— insomnia; paroxetine & Fluvoxamine—most sedating Monitorin g ECG; reassess SI, ADR after 2-4wks of starting meds Dietary restrictions needed such as aged meat, cheeses, fermented foods Monitor closely during first 2- 3 wk of initiation of SRIs Therapeutic benefits take 3-4 wks Taper off med: reduce dose by 50% 3-4days Serotonin-
Image of page 5
Image of page 6

You've reached the end of your free preview.

Want to read all 13 pages?

  • Spring '14
  • Henrikson,J
  • Major depressive disorder

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern

Stuck? We have tutors online 24/7 who can help you get unstuck.
A+ icon
Ask Expert Tutors You can ask You can ask ( soon) You can ask (will expire )
Answers in as fast as 15 minutes
A+ icon
Ask Expert Tutors