packaging informed conditions at normal room teC and to be

Packaging informed conditions at normal room tec and

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packaging informed conditions at normal room temperature (20°-25°C) and to be protected from moisture. The objective of the study is to analyze a potential decrease in potency of the cetirizine by forced degradation under conditions that exceed the recommended storage conditions on the packaging by the Rising manufacturer. A comparison with acetaminophen and aspirin will be carried out for identification of possible similar degradation. Exceeding the conditions will promote formation of new compounds in the pill as a result of cetirizine degradation. The inactive ingredients (excipients) serve a purpose to the manufacturing process of pharmaceutical products in the tablets and protection of pill contents encased with the film coating, however, it may often have the potential to expedite degradation reactions. [1] The chemical stability of pharmaceutical products is identified of importance, but not exclusively to the consumers, pharmaceutical companies, military and NASA. The International Space Station (ISS) ensure that medications get restocked before the expiration date to prevent degradation, however, it may not be feasible to achieve during long-term missions. [2] The Figure 1 . Structure of Cetirizine
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expiration date was controlled in the cetirizine study, yet it contributes to surpass the recommended conditions of the reported spaceflight study. In this study, the degradation of cetirizine was investigated that have been exposed to harsh storage conditions, specifically high heat (75°C) and 70.0% relative humidity (RH). One cetirizine pill sample will be prepared at each of these time points: No exposure (control), 1-week exposure, 3 weeks exposure, 5 weeks exposure, and 7 weeks exposure. Following the finalization of the exposure time, an analysis of possible formation of new compounds will be observed as a result of cetirizine degradation.
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References 1. Cory, W. C., Harris, C., & Martinez, S. (2010). Accelerated degradation of ibuprofen in tablets. Pharmaceutical Development and Technology , 15 (6), pp. 636-43. doi:10.3109/10837450903426518. 2. Wotring, V.E. Chemical Potency and Degradation Products of Medications Stored Over 550 Earth Days at the International Space Station. The AAPS Journal 2016, 18 , 210-216.
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