Note that the dosage reduction withdrawal schedule is flexible and should be

Note that the dosage reduction withdrawal schedule is

This preview shows page 23 - 26 out of 30 pages.

Note that the dosage reduction withdrawal schedule is flexible and should be tailored to each individual patient. Dose Number of 5 mg tablets/day Number of 5 mg tablets/week Starting dose Nitrazepam 20 mg 4 28 Stage 1 (1–2 weeks) Nitrazepam 15 mg 3 21 Stage 2 (1–2 weeks) Nitrazepam 12.5 mg 18 Stage 3 (1–2 weeks) Nitrazepam 10 mg 2 14 Stage 4 (1–2 weeks) Nitrazepam 7.5 mg 11 Stage 5 (1–2 weeks) Nitrazepam 5 mg 1 7 Stage 6 (1–2 weeks) Nitrazepam 2.5 mg ½ 4 Stage 7 (1–2 weeks) Nitrazepam 2.5 mg alternate nights ½ 2 Stage 8 Stop nitrazepam Temazepam Start from the most relevant point of the schedule depending on the patient’s current dose. Note that the dosage reduction withdrawal schedule is flexible and should be tailored to each individual patient. Dose Number of 10 mg tablets/day Number of 10 mg tablets/week Starting dose Temazepam 30 mg 3 21 Stage 1 (1–2 weeks) Temazepam 25 mg 18 Stage 2 (1–2 weeks) Temazepam 20 mg 2 14 Stage 3 (1–2 weeks) Temazepam 15 mg 11 Stage 4 (1–2 weeks) Temazepam 10 mg 1 7 Stage 5 (1–2 weeks) Temazepam 5 mg ½ 4 Stage 6 (1–2 weeks) Temazepam 5 mg alternate nights ½ 2 Stage 7 Stop temazepam Page 23 of 30
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All Wales Medicines Strategy Group Lormetazepam Start from the most relevant point of the schedule depending on the patient’s current dose. Note that the dosage reduction withdrawal schedule is flexible and should be tailored to each individual patient. Dose Number of 500 microgram tablets/day Number of 500 microgram tablets/week Starting dose Lormetazepam 1.5 mg 3 21 Stage 1 (1–2 weeks) Lormetazepam 1 mg 2 14 Stage 2 (1–2 weeks) Lormetazepam 500 micrograms 1 7 Stage 3 (1–2 weeks) Lormetazepam 250 micrograms ½ 4 Stage 4 (1–2 weeks) Lormetazepam 250 micrograms alternate nights ½ 2 Stage 5 Stop lormetazepam Zopiclone Start from the most relevant point of the schedule depending on the patient’s current dose. Note that the dosage reduction withdrawal schedule is flexible and should be tailored to each individual patient. Dose Number of tablets/day Number of tablets/week Starting dose Zopiclone 15 mg 2 x 7.5 mg 14 x 7. 5 mg Stage 1 (1–2 weeks) Zopiclone 11.25 mg 1 x 7.5 mg 1 x 3.75 mg 7 x 7.5 mg 7 x 3.75 mg Stage 2 (1–2 weeks) Zopiclone 7.5 mg 1 x 7.5 mg 7 x 7.5 mg Stage 3 (1–2 weeks) Zopiclone 3.75 mg 1 x 3.75 mg 7 x 3.75 mg Stage 4 (1–2 weeks) Zopiclone 3.75 mg alternate nights 1 x 3.75 mg 4 x 3.75 mg Stage 5 Stop zopiclone Zolpidem Start from the most relevant point of the schedule depending on the patient’s current dose. Note that the dosage reduction withdrawal schedule is flexible and should be tailored to each individual patient. Dose Number of tablets/day Number of tablets/week Starting dose 10 mg 2 x 5 mg 14 x 5 mg Stage 1 (1–2 weeks) 7.5 mg 1½ x 5 mg 11 x 5 mg Stage 2 (1–2 weeks) 5 mg 1 x 5 mg 7 x 5 mg Stage 3 (1–2 weeks) 2.5 mg ½ x 5 mg 4 x 5 mg Stage 4 (1–2 weeks) 2.5 mg alternate nights ½ x 5 mg 2 x 5 mg Stage 5 Stop zolpidem 4k) Reduction protocols to support the withdrawal from anxiolytics Page 24 of 30
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Material to Support Appropriate Prescribing of Hypnotics and Anxiolytics across Wales Different withdrawal plans are given for guidance only. The rate of withdrawal should be individualised according to the drug, dose, and duration of treatment.
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  • Summer '07
  • HARRIS-WARRICK,R.M.
  • Benzodiazepine, diazepam, Temazepam

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