Metformin does not undergo hepatic metabolism nor biliary excretion. ◦Contraindications-Contraindicated in patients with severe renal impairment (eGFR below 30 mL/min/1.73 m2), acute or chronic metabolic acidosis, including diabetic ketoacidosis, a history of hypersensitivity reaction to linagliptin, such as anaphylaxis, angioedema, exfoliative skin conditions, urticaria, or bronchial hyperreactivity, or a history of hypersensitivity reaction to metformin.◦Black box warnings- Lactic acidosis is a rare but a serious side effect. Symptoms include weakness, unusual muscle pain, trouble breathing, unusual sleepiness, and stomach pains.◦(Woo 2015).
References◦Jarvis, S. (2008). Prescribing choices in type 2 diabetes.Practice Nurse,35(8), 23-26.◦American Diabetes Association (ADA). Standards of Medical Care in Diabetes. 2018. Retrieved from (AACC.orghtpps://). ◦Woo, T.M. (2015). Pharmacotherapeutics for Advances Practice Nurse Prescribers with DavisPlus Resources, 4thEdition. (South University).
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- Fall '16
- Diabetes, Blood sugar, blood sugar level