Both the MHP medial hinge point and DLHP dorsolateral hinge point undergo

Both the mhp medial hinge point and dlhp dorsolateral

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Both the MHP (medial hinge point) and DLHP (dorsolateral hinge point) undergo apical constriction As we just saw, the epidermis expresses BMPs and the notochord expresses Shh Noggin is expressed in the dorsal neural tube Let’s take a look at how these signals coordinate folding...
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What regulates neural tube folding? Methods: Examine 73353RLLNQ mutant mice stained for a marker of the neural folds. Observations: Conclusions: --1--/NQW)# &&*&IIUJVV HFSNJHHFO JHRQVWUNJHWNRQ HFQI SRWJQWNHFO UROJV KRU ''+'2622495575V° Dorsal views of mouse neural tube
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What regulates neural tube folding? ''+'HFVJI RQ WMJ SUJYNRXV J[SJUNPJQW± ZMHFW JKKJJHWV IR \RX SUJINJHW WMHFW JHFJHM ZNOO MHFYJ RQ HFSNJHHFO JHRQVWUNJHWNRQ$$($ Methods: Perturb BMP signaling levels using either: A constitutively active BMP receptor Or A dominant negative BMP receptor
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What regulates neural tube folding? Methods: Perturb BMP signaling levels using either: A constitutively active BMP receptor Or A dominant negative BMP receptor Green (GFP) = electroporated cells Blue (DAPI) = nuclei Red (Par3) = apical membranes.
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What regulates neural tube folding? Methods: Perturb BMP signaling levels using either: A constitutively active BMP receptor Or A dominant negative BMP receptor
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What regulates neural tube folding? Compare the non-hinge regions to the MHP and address: BMP signaling levels SMAD activation cell shape nuclear localization apical constriction
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Discuss the OHFWJ events of neurulation... Orient yourself to the axes Focus on positions of the epidermis and neural plate <<><MHFW HFUJ WMJ PHFMRU PRUSMRLJQJWNJH JHMHFQLJV$$($
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Discuss the OHFWJ events of neurulation... Transverse sections of mouse neural tube Epidermis Neural folds
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Discuss the OHFWJ events of neurulation... Dorsal surface of mouse neural tube Epidermis
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What movement(s) drive neural tube closure? A. Epiboly B. Convergent extension C. Zippering D. Apical constriction E. Cell crawling F. Two of the above G. Three of the above H. Four of the above I. All of the above J. None of the above Text JEFFRAS to 22333 Respond at PollEv.com/JEFFRAS Neural tube closure in ((,(NRQHF Hashimoto … Munro, ))-))JY ((,(JOO 2015
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What movement(s) drive neural tube closure?
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  • Fall '17
  • Brian Buchwitz

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