result in cardiac effects of beta 1 unless high doses are administered most

Result in cardiac effects of beta 1 unless high doses

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result in cardiac effects of beta 1 unless high doses are administered, most significant adverse effect: tremor & tachycardia (caused by excessive use) Terbutaline:tocolytic and bronchodilator used to treat asthma, bronchitis and emphysema or to prevent preterm laborAlpha 2 Agonist-works within the synapse to decrease NE which results in vasodilation, which decreases BP, specifically at the brainstem Clonidine:hypertension, severe pain, ADHD, can cause bradycardia, decrease in cardiac output and promotes vasodilation resulting in decreased BP. Adverse effects: drowsiness, xerostomia (dry mouth), rebound hypertension, cannot be used in pregnant women, abuse, avoid abrupt discontinuation, wean-off over four days to avoid rebound hypertension Off label: smoking cessation, Tourette’s & methadone withdrawal Methyldopa: oral antihypertensive agent that lower BP by acting in the CNS, two side effects hemolytic anemia and hepatic necrosis Adrenergic Antagonists Block the effects of sympathetic stimulation
Sympatholytic- cut sympathetic nervous system Block alpha-1, beta, or both; selectively or notAlpha 1 blockers Selectively block alpha-1, some are also beta-blockersEffects classified as “centrally-acting” (indirect; alpha-2 agonists) and “peripherally-acting” (direct; alpha-1 antagonists- work at the vessel level)Limit the vasoconstrictive effects of alpha-1 stimulation to cause vasodilation (blockers) or inhibitrelease of epinephrine from CNS receptors (alpha-2 agonists)Cause relaxation of bladder neck muscle (BPH)Clinical Use Treatment of HTN, reduce toxicity of alpha-1 drugs, treatment of extravasation of IV alpha-agonists, Raynaud’s diseaseTreatment of BPH, pheochromocytoma (adrenal gland tumor)Adjunctive therapy for pain, ADHD, opioid withdrawal Side/Adverse Effects

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