be7a011a4b99345234342df95dce87b8d414.pdf

Genes which are responsible for the coding of target

Info icon This preview shows pages 1–3. Sign up to view the full content.

genes, which are responsible for the coding of target proteins, in addition to identifying new targets that offer Mini Review Volume 1 Issue 5 Received Date : August 09, 2017 Published Date: August 17, 2017
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

Open Access Journal of Pharmaceutical Research Reddy MA. Bioinformatics-Key to Drug Discovery and Development. J Pharm Res 2017, 1(5): 000126. Copyright© Reddy MA. 2 more potential for new drugs [5,6]. This is an area where the human genome information is expected to play a master role [7]. Drug developers are presented with an unaccustomed luxury of choice as more genes are identified and the drug discovery cycle becomes more data-intensive [8]. Bioinformatics allows the identification and analysis of more and more biological drug targets; thus expected to greatly increase the breath of potential drugs in the pipelines of pharmaceutical companies [2,3]. S. No Database Information 1 Drug bank Wishart, et al.[9] The Drug Bank database is a blended bioinformatics and chemo informatics resource that combines detailed drug (i.e., chemical, pharmacological and pharmaceutical) data with comprehensive drug target(i.e., sequence, structure, and pathway) information 2 Therapeutic target DB Zhu, et al. [10] The therapeutic target database (TTD) is a drug database designed to provide information about the known therapeutic protein and nucleic acid targets described in the literature, the targeted disease conditions, the pathway information and the corresponding drugs/ligands directed at each of these targets 3 STITCH Kuhn, et al. [11] STITCH (‘search tool for interactions of chemicals’) is a searchable database that integrates information about interactions from metabolic pathways, crystal structures, binding experiments and drug-target relationships. Text mining and chemical structure similarity is used to predict relations between chemicals. Each proposed interaction can be traced back to the original data sources 4 Super Target Hecker, et al. [12] Super Target is a database that contains a core dataset of about 7,300 drug-target relations of which 4,900interactions have been subjected to a more extensive manual annotation effort. Super Target provides tools for 2D drug screening and sequence comparison of the targets Table 1: Drug Target Database. Drug Target Validation Bioinformatics also provides strategies and algorithm to predict new drug targets and to store and manage available drug target information. After the discovery of ‘‘potential’’ drug targets, there is an inappreciable need to establish a strong association between a putative target and disease of interest [7]. The establishment of such a key association provides justification for the drug development process. This process, known as target validation, is an area where bioinformatics is playing a significant role (Figure 1). Drug target validation helps to moderate the potential for failure in the clinical testing and approval phases [2].
Image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern