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Bone gets dropped on top of cartilageb.v.Osteoblasts are used to replace cartilage with bone b.vi.Interstitially b.vi.1.Pushing each bone into each direction c.Secondary Ossification Center Events c.i.Both cartilages don’t have a perichondrium c.ii.Epiphyseal cartilage will get nutrients from the bone and the articulating cartilage will get nutrients from the synovial fluid d.Bone Growth d.i.When there is a line on the bone that means that bone can’t be grown in length. d.ii.Cartilage cells divide as osteoblasts are laid on top of them to create bone, hydroxyapatite and collagen fibers. d.iii.Zone of ossificationd.iii.1.Where bone is replaced by cartilage d.iv.Estrogen has a greater effect on osteoblast ability to divide and replace cartilage with bon faster than testosterone, osteoblasts replace epiphyseal cartilage faster than in males d.iv.1.This is the reason why females are typically shorter than males because their growth plate grows faster than malesd.v.Achondroplastic dwarfism d.v.1.No problem with cartilage growth
d.v.2.Bone doesn’t replace the cartilage, problem with osteoblasts d.v.3.Problem is ossification 5.The Dynamic Nature of Bone a.Tendons attach to the bone structures b.Tendons pull on the bones thus the force is transduced to the tendons c.When you exercise you can increase the density of your bone c.i.When you excerise you create tension in your tendons c.ii.Radial tuberosity c.ii.1.Withstanding a lot of stress c.ii.2.That stress stimulates osteoblasts to start building up bonein the direction where the stress is applied c.iii.Stress on bone will stimulate the bone to grow in the direction the stress is applied c.iv.Osteoclasts c.iv.1.When osteoblasts are building up bone, osteoclasts are used to sculpt the bone d.The reason why you have spongy bone is so that we can withstand stress from all directions e.The reason why we have compact bone in the diaphysis e.i.Compact bone is most strongest in this area e.ii.Osteons are lined up in a direction f.With bones it’s also about distributing stresses across your bones 6.Bones are Calcium Reserve a.Hypocalcaemiaa.i.Low blood calcium a.ii.Factors to increase blood calcium a.ii.1.PTH (parathyroid Hormone)