Example Femur biv Bone gets dropped on top of cartilage bv Osteoblasts are used

Example femur biv bone gets dropped on top of

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Example: Femur b.iv. Bone gets dropped on top of cartilage b.v. Osteoblasts are used to replace cartilage with bone b.vi. Interstitially b.vi.1. Pushing each bone into each direction c. Secondary Ossification Center Events c.i. Both cartilages don’t have a perichondrium c.ii. Epiphyseal cartilage will get nutrients from the bone and the articulating cartilage will get nutrients from the synovial fluid d. Bone Growth d.i. When there is a line on the bone that means that bone can’t be grown in length. d.ii. Cartilage cells divide as osteoblasts are laid on top of them to create bone, hydroxyapatite and collagen fibers. d.iii. Zone of ossification d.iii.1. Where bone is replaced by cartilage d.iv. Estrogen has a greater effect on osteoblast ability to divide and replace cartilage with bon faster than testosterone, osteoblasts replace epiphyseal cartilage faster than in males d.iv.1. This is the reason why females are typically shorter than males because their growth plate grows faster than males d.v. Achondroplastic dwarfism d.v.1. No problem with cartilage growth
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d.v.2. Bone doesn’t replace the cartilage, problem with osteoblasts d.v.3. Problem is ossification 5. The Dynamic Nature of Bone a. Tendons attach to the bone structures b. Tendons pull on the bones thus the force is transduced to the tendons c. When you exercise you can increase the density of your bone c.i. When you excerise you create tension in your tendons c.ii. Radial tuberosity c.ii.1. Withstanding a lot of stress c.ii.2. That stress stimulates osteoblasts to start building up bone in the direction where the stress is applied c.iii. Stress on bone will stimulate the bone to grow in the direction the stress is applied c.iv. Osteoclasts c.iv.1. When osteoblasts are building up bone, osteoclasts are used to sculpt the bone d. The reason why you have spongy bone is so that we can withstand stress from all directions e. The reason why we have compact bone in the diaphysis e.i. Compact bone is most strongest in this area e.ii. Osteons are lined up in a direction f. With bones it’s also about distributing stresses across your bones 6. Bones are Calcium Reserve a. Hypocalcaemia a.i. Low blood calcium a.ii. Factors to increase blood calcium a.ii.1. PTH (parathyroid Hormone)
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a.ii.1.a. Osteoclasts are running the buffer equation to the right which produces protons which is used on bones to dissolve the hydroxyapatite, which liberates the calcium to the blood. a.ii.1.b. Used to prevent kidney calcium loss in urine, increase blood calcium a.ii.1.c. Calcitrial and PTH work together to facilitate calcium intake in your lining of the small intestines, a.iii. Factors to decrease blood calcium a.iii.1. Hypercalcaemia a.iii.2. Decreased PTH a.iii.3. Excrete calcium to your urine a.iii.3.a. Calcitonin a.iii.3.a.i. Shuts osteoclasts down a.iii.3.a.ii. Has a binding site for calcitonin a.iii.3.a.iii. Shutting down an osteoclasts a.iii.3.a.iii.1. You increase osteoblast activity a.iii.3.a.iii.2. When you have osteoblast
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