Amusing aside both of the examples from jacob and

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Amusing aside: both of the examples from Jacob and Monod involve DNA looping, a form of biochemistry on a leash.
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Chance Caught on a Wing: Decision Chance Caught on a Wing: Decision Making and Evolution Making and Evolution (Berman et al .) Concept: study of wing patterns of gene expression a model system for probing how genes are deployed in space and time and, more importantly, a particular evolutionary mechanism. The concept: compare different species of fly that have different patterns on their wings. The conclusion: Not changes in the proteins themselves, just changes in the decision about which genes are turned on or off. (Prud’homme, Gompel and Carroll, PNAS, 2007) (Wray, Nature, 2006)
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Chance Caught on a Wing: Decision Chance Caught on a Wing: Decision Making and Evolution Making and Evolution (Berman et al .) DNA molecules as “documents of evolutionary history” - these sequences are a stopwatch! (Prud’homme, Gompel and Carroll, et al., Nature, 2006) This figure illustrates how the regulatory genome changes over evolutionary time. Physical question that remains as fun challenge: what is the mechanism of action at a distance?
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Chance Caught on a Wing: Decision Chance Caught on a Wing: Decision Making and Evolution Making and Evolution (Berman et al .) Molecules as “documents of evolutionary history” can be used to examine relatedness of flies. (Prud’homme, Gompel and Carroll, et al., Nature, 2006)
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Fun Case Studies: Changes in Body Fun Case Studies: Changes in Body Plan in Fish Plan in Fish Stickleback fish separated after last ice age more than 10,000 years ago. Morphologically, fresh water and salt water versions all differ. Some of the interesting features include pelvic reduction and the nature of their armor. Fantastic conclusion - changes not necessarily induced by changes in protein coding regions. These studies merge genetics with molecular analysis and evolutionary biology. Stunning window onto how novelty is generated in body plans. David Kingsley group, Stanford University
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The Ingredients of Evolution: Natural The Ingredients of Evolution: Natural Selection Selection If the offspring have different success (``fitness’’), they will yield more offspring and will drive the population in new directions. An exciting and concrete case study is that of the rock pocket mouse, some of which live on lava rock and are most often dark colored. Modest changes in a receptor protein suffice to change the color. Recurring theme! PNAS | April 29, 2003 | vol. 100 | no. 9 | 5268-5273
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Chance Caught on a Wing: Decision Chance Caught on a Wing: Decision Making and Evolution Making and Evolution (Berman et al .) DNA molecules as “documents of evolutionary history” - these sequences are a stopwatch! (Prud’homme, Gompel and Carroll, PNAS, 2007) (Prud’homme, Gompel and Carroll, et al., Nature, 2006)
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  • Fall '19
  • DNA, Berman

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