Rbcs initial hg level not accurate bc high a false

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RBCs; initial Hg level not accurate b/c high (a false increase) b/c they’ve lost a lot of water and fluid so 1 st thing they do w/ burn patients in hydrate them Extrinsic Due to Immune Causes RBCs have antibody already attached to it; depending on site, may be extravascular/intravascular; in most cases its extravascular Pg. 326-327 Autoimmune Hemolytic Anemia – You yourself have made the antibodies to your own RBCs; it’s the only disease you can diagnose in blood banking; can be either warm or cold type depending on where rx is; If it rxs at body temperature= warm type (warm reactive antibodies); If rxs below body temperature = cold type (cold reactive antibodies); In most cases more concerned w. the warm type causing problems;
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Test= a direct antiglobulin test (results go from 0 to +4); in most cases extravascular hemolysis – phagocytic cells in spleen – Trx w/ splenectomy; age of onset= any age Drug Induced Hemolytic Anemia – Just another cause – not going to go in depth right now; Trx – stop drug trx Alloimmune Hemolytic Anemias Produce antibodies to someone else’s RBCs; allo = other 1.) Hemolytic Transfusion Rxs -another cause of hemolytic anemias (in depth next semester) 2.) Hemolytic Disease of the Newborn (i.e. concerning Rh blood group) *****+ DIRECT ANTIGLOBULIN TEST – FOR ALL OF THE IMMUNE (AUTO, ALLO, DRUG) HEMOLYTIC ANEMIAS**** LEUKOCYTE DISORDERS PG. 373 Used to be called nonmalignant – now called morphological and distributive leukocyte disorders Look @ RR and compare #s Philia = increase in a specific cell line
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