Patient’s should verify with their cardiologist about specific activity guidelines (Cleveland Clinic, 2018). Genetic counseling should be performed prior to pregnancy as Marfan syndrome is an inherited condition (Cleveland Clinic, 2018). Pregnant women with Marfan syndrome are considered high risk cases (Cleveland Clinic, 2018). If the aorta is normal size, the risk for dissection is lower, but not absent (Cleveland Clinic, 2018). Those with even slight enlargement are at higher risk and the stress of pregnancy may cause more rapid dilation (Cleveland Clinic, 2018). Careful follow-up, with frequent blood pressure checks and monthly echocardiograms is required during pregnancy (Cleveland Clinic, 2018). If there is rapid enlargement or aortic regurgitation, bed rest or surgery may be required (Cleveland Clinic, 2018). People with Marfan syndrome who have also had valve surgery have an increased risk for bacterial endocarditis (Cleveland Clinic, 2018). To reduce the risk of endocarditis, antibiotics should be given prior to dental or surgical procedures in patients with Marfan syndrome who have had valve surgery (Cleveland Clinic, 2018). It is important to educate patient/families to
check with their provider about the type and amount of antibiotics that should be taken (Cleveland Clinic, 2018). A wallet card may be obtained from the American Heart Association with specific antibiotic guidelines (Cleveland Clinic, 2018). Summary A better understanding of Marfan syndrome combined with earlier detection, careful follow-up, and safer surgical techniques have resulted in better outcomes for patients. While Marfan syndrome is a condition that cannot be cured, patients can live a long, full life with proper treatment and management. References Burns, C. E., Dunn, A. M., Brady, M. A., Starr, N. B., Blosser, C. G., & Garzon, D. L. (2017). Pediatric primary care (6th ed.). St. Louis, MO: Elsevier, Inc. Chandra, A., Patel, D., Aragon-Martin, J. A., Pinard, A., Collod-Béroud, G., Comeglio, P., Arno, G. (2015). The revised ghent nosology; reclassifying isolated ectopia lentis. Clinical Genetics , 87 (3), 284–287. Cleveland Clinic. (2018). Marfan Syndrome. Retrieved from Dean, J. C. S. (2012). Management of Marfan syndrome. Heart , 88 (1), 97–103. Marfan Foundation. (2014). Marfan Syndrome. Retrieved from National Library of Medicine. (2012). Lujan syndrome. Retrieved from National Organization for Rare Disorders. (2017). Shprintzen Goldberg Syndrome. Retrieved from
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