Pentazocine Talwin Relief of moderate to severe pain preferred drug for

Pentazocine talwin relief of moderate to severe pain

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Narcotic Agonists–Antagonists (cont.) Pentazocine ( Talwin ) Relief of moderate to severe pain, preferred drug for patients switched from parenteral to oral forms after surgery or labor
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Narcotic Agonists–Antagonists (cont.) Narcotic Agonists–Antagonists (cont.) Actions Act at a specific opioid receptor sites in the CNS to produce analgesia, sedation, euphoria, and hallucinations Indications Moderate to severe pain Adjunct to general anesthesia Relief of pain during labor and delivery
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Narcotic Agonists–Antagonists (cont.) Narcotic Agonists–Antagonists (cont.) Pharmacokinetics Readily absorbed IM and reach peak levels rapidly when given IV Metabolized in the liver excreted in urine or feces Cross placenta Contraindications Known allergy Pregnancy and lactation
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Narcotic Agonists–Antagonists (cont.) Narcotic Agonists–Antagonists (cont.) Cautions Avoid using with patients with physical dependence on a narcotic COPD and disease of the respiratory tract Acute MI or documented CAD Renal/Lever dysfunction Adverse Reactions Respiratory depression Nausea, vomiting, constipation, and biliary spasm Dizziness, psychosis, anxiety, hallucination Dependency < Narcotics
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Narcotic Agonists–Antagonists (cont.) Narcotic Agonists–Antagonists (cont.) Adverse Reactions Headache Dizziness Psychoses Anxiety Hallucinations Ureteral spasm, urinary retention
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Drug to Drug Interactions Drug to Drug Interactions Anesthetics and barbiturates -> Increase respiratory depression, hypotension, and sedation Pentazocine (Talwin) + tripelennamine (T’s and blues) combination abused for hallucinogenic and euphoric effect can be fatal complications.
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Nursing Considerations for Narcotics Agonists-Antagonists Nursing Considerations for Narcotics Agonists-Antagonists Assess Pre-Administration: History- Respiratory dysfunction, CVD, PG/Breast feeding, renal/liver dysfunction Physical Exam- VS, Pain for baseline status, CNS orientation, affect, reflexes, respiratory status, lung sounds, bowel sounds, urinary output Known allergy Lab- liver/renal function, ECG tests
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Nursing Considerations Cont. Nursing Considerations Cont. Post Administration Care Assess-Pain status, VS, LOC, skin, lung sounds & respiratory status, BP, HR Labs-LF, Kidney Safety- Comfort measures (heat, positioning etc.), safety measures, assist with ambulation, initiate bowel program Patient teaching-AE, No alcohol, avoid driving, getting assistance with ambulation, risk for physical dependency, need for periodic monitoring & evaluation Things to remember- Use additional measures to relieve pain, administer small frequent meals to relieve GI upset, Discontinuing & Overdose/Toxicity-
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Prototype Narcotic Agonists–Antagonists Prototype Narcotic Agonists–Antagonists
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