Symptoms cracks and redness of lips and corners of

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Symptoms: cracks and redness of lips and corners of the mouth, swelling of the mouth and sore throat Riboflavin deficiency may be seen with chronic alcohol abuse or malabsorptive conditions Pyridoxine (B6) Deficiency can cause various symptoms Anemia Impaired immune function Weakness Dermatitis Neurological disorders 10. Folate 1. Functions Acts as a coenzyme in metabolism of certain amino acids Helps in DNA and RNA synthesis Helps with normal cell division and development 2. Supplementation (which demographic?) Folate is in the form of folic acid in supplements and fortified foods pregnant women should have 600 mcg compared to the recommended 400 mcg 3. Deficiency issues (NTD) Folate deficiency causes megaloblastic anemia Inadequate intake increases risk of neural tube defects
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11.Vitamin B12 1. Functions Largest and most complex chemical structure Contains the mineral cobalt B12 CHEMICAL name is cobalamin B12 in food is bound to proteins Requires gastric acid and intrinsic factor in stomach for absorption B12 acts as a coenzyme in two important reactions Deriving energy from amino acids Converting the amino acid homocysteine to methionine Indispensable for activating folate 2. Supplementation (which demographic?) Groups at risk of deficiency that might need supplementations Vegans Gastric bypass patients Elderly Individuals with pernicious anemia (lack intrinsic factor) 12.Antioxidants (sources) 1. Vitamin E (functions/sources) functions incorporated into cell membranes antioxidant protecting against oxidative damage neutralizes free radicals and breaks the chain of oxidative damage healthy immune function antioxidant!! sources almonds many nuts and some oils 2. Vitamin C (functions/sources) – immune function, supplementation? Functions Acts as a coenzyme in biological reactions Aids in hormone production Involved in collagen synthesis Enhances iron absorption Antioxidant Sources Found in many fruits and some vegetables, but it is readily destroyed by storage and cooking Supplementation cannot cure the common cold 3. Free Radicals Free radicals are produced continuously in the cells as part of normal cellular function , however excess production might play a role in pathophysiology of many disease conditions, including cancer, Alzheimer's disease, atherosclerosis and some of the drug- induced toxicity. A free radical can be defined as any molecular species capable of independent existence that
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contains an unpaired electron in an atomic orbital The presence of an unpaired electron results in certain common properties that are shared by most radicals Many radicals are unstable and highly reactive Cells may function poorly or die if this occurs. To prevent free radical damage the body has a defense system of antioxidants. Antioxidants are molecules which can safely interact with free radicals and terminate the chain reaction before vital molecules are damaged 4. Oxidation 5. Disease prevention function
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