Nielsen1300_Wk12_Lect1_CMN.ppt

Process of making transmission easier immediate short

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: process of making transmission easier Immediate, short- and long-term memory Correlate with different modes of synaptic potentiation 20
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Immediate memory Ability to hold something in your thoughts for a few seconds Example: reading Timescale = few seconds 21
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Short-term memory Working memory for taking action Example: typing address into GPS – will be quickly forgotten if you stop reciting it Timescale = few seconds to few hours Tetanic stimulation : rapid arrival of repetitive signals at a synapse (brief memories) Ca 2+ accumulation; makes postsynaptic cell more likely to fire Posttetanic potentiation : jogging a memory from a few hours ago Ca 2+ level in synaptic knob stays elevated; easier to excite postsynaptic cell Little stimulation needed to recover memory 22
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Long-term memory: timescale = may last a lifetime Declarative: retention of events you can put into words (dates, #s) Procedural: retention of motor skills (riding a bike) 23
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Long-term memory: timescale = may last a lifetime STRUCTURAL CHANGES : May involve remodeling synapses or forming new ones Dendritic spines Increase surface area of synaptic contact 24
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Long-term memory: timescale = may last a lifetime MOLECULAR CHANGES : May involve long-term potentiation NMDA receptors bind glutamate & receive stimulus Ca 2+ enters cell & acts as second messenger: More NMDA receptors are produced Proteins involved in synapse remodeling are synthesized Signals more neurotransmitter release from presynaptic neuron Glutamate only Glutamate + Depolarization Stimulus 25
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Long-term memory: timescale = may last a lifetime MOLECULAR CHANGES : May involve long-term potentiation NMDA receptors bind glutamate & receive stimulus Ca 2+ enters cell & acts as second messenger: More NMDA receptors are produced Proteins involved in synapse remodeling are synthesized Signals more neurotransmitter release from presynaptic neuron 26
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Long-term memory: timescale = may last a lifetime Initial state 1 week later Repeated stimulation Long-term potentiation 27
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