Releasing inhibiting hormone pituitary tropic hormone

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Releasing/ inhibiting hormone Pituitary Tropic hormone Hypothalamic hypophysiotropic neurons Suppose an individual comes to clinic and is exhibiting very low circulating concentrations of the hormone of interest? Where in the pathway could the defect occur? How would you know which possibility is correct? X X
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*Tropic hormones: /Regulate hormone secretion by another endocrine gland /Stimulate and maintain their endocrine gland target tissues Fig. 18(5, p. 667 Hormones of the anterior pituitary TSH: Thyroid Stimulating Hormone * ACTH: Adrenocorticotropic hormone * LH: Leutinizing hormone * FSH: Follicle Stimulating Hormone * GH: Growth hormone * PRL: Prolactin
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Hypothalamic releasing hormone (or inhibiting hormone) Growth hormone releasing hormone (GHRH) Corticotropin releasing hormone (CRH) Thyrotropin releasing hormone (TRH) Gonadotropin releasing hormone (GnRH) Anterior pituitary tropic hormone Growth hormone (GH) Adrenocortico; tropic hormone (ACTH) Thyroid stimulating hormone (TSH) Luteinizing hormone (LH) Follicle stimulating hormone (FSH) Endocrine organ Liver Adrenal cortex Thyroid Gonads Peripheral hormone(s) Insulin;like growth factor I (IGF;1) Glucocorticoids T3, T4 Sex hormones Hypothalamic: pituitary: control of hormone secretion
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ng/mlGH 3 10 20 Hours after onset of sleep 1 3 5 Growth hormone (GH): Regulator of somatic cell growth and metabolism Fig. 18(10, p. 656
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Growth effects of growth hormone: Direct and indirect (via local IGF91 production) Promotes long bones growth until puberty: estradiol accelerates bone building osteoblasts that catch up and seal growth plate (in both sexes!) Thyroid hormone is permissive for effects of GH ( GH receptor) Fig. 18(9, p655 IGF$1 stimulates chondrocyte growth and osteoclast differentiation
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Pathophysiology of growth hormone excess and insufficiency Fig. 18;11 & 18;12, p. 657
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*Tropic hormones: /Regulate hormone secretion by another endocrine gland /Stimulate and maintain their endocrine gland target tissues Fig. 18(5, p. 667 Hormones of the anterior pituitary TSH: Thyroid Stimulating Hormone * ACTH: Adrenocorticotropic hormone * LH: Leutinizing hormone * FSH: Follicle Stimulating Hormone * GH: Growth hormone * PRL: Prolactin *
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*Tropic hormones stimulate and maintain their target tissue Stress-associated adrenal hypertrophy Control Chronic stress 0.00 0.05 0.10 0.15 0.20 g/kg*bw ** *due to greater and prolonged stimulation by ACTH Adrenalmass
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Fig. 19(7, p. 693 The Adrenal Glands
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The adrenal cortex releases lipophilic (steroid) hormones Aldosterone Angiotensin II Low blood pressure
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1. Aldosterone acts via mineralocorticoid receptor (MR) on the distal and collecting tubules of the kidney, resulting in expansion of plasma volume, which should increase blood pressure.
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  • Spring '08
  • Fuller,Charles/Goldberg,Jack
  • Physiology, ACTH, Cortisol, Anterior pituitary

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