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Newman, et al., 2011;Sidhu, et al., 2012b).In addition to this, the survival rate is relatively higher among the patients who used steroidas compared to the placebo group that showed the ALT levels more than and equal to 30ULN. It indicates the treatment with corticosteroids is effective for the improvement ofdisease progression with the potentially speedy progression (Newman, et al., 2011; Sidhu, etal., 2012b).Hepatic encephalopathy (HE) and the MELD scores work as a vital indicators for the severityof the disease which is associated to the liver disease’s progression. The HE grade at 4indicates that the survival rate for the patients was extremely low however the grade 1-3showed a higher survival rate among the patients who used steroids for the treatment (Forrest,et al., 2013; Mathurin, et al., 2013). The serum ALT, HE grades and MELD scores associatedto the impacts of prognosis and treatment of liver disorder. The results of meta-analysis©<Your name> 201916of41
SYSTEMATIC REVIEWstudies showed that the survival rate’s predictor as well as the potential risk for theprogression of disease should be undertaken for the assessment of the corticosteroid treatmentalong with the liver disease progression (Newman, et al., 2011; Sidhu, et al., 2012a; Forrest,et al., 2013; Mathurin, et al., 2013.The very high levels of ALT indicated that the patients are at a risk of disease progression.But it is also an indicator of the extensive degeneration and hepatocyte necrosis. It suggeststhat the patient are in early prognosis. The use of steroids is ineffective if the degenerativehepatocyte is damaged (Fujiwara et al., 2008).Fujiwara et al (2008) studied eight patients forthe administered steroids for less than 10 days after the liver disease was diagnosed.Nevertheless, more than 88 % individuals showed a complete recovery after the treatment ofsteroids for 10 days. It concludes that the total time span between the symptoms prognosisand the treatment initiation was shorter among survivors as compared to non-survivors. Therate of survival increased significantly among the patients with corticosteroid administeredgroup for less than 2 weeks as compared to the patients that were treated for more than 2weeks. It shows that the timing of corticosteroid treatment is critical for the attenuation of theliver disease frequency. This study also reveals that the survival rate was above 64% amongthe patients that showed less than 35 MELD score and <4 HE grade. Nevertheless, the rate ofsurvival was merely 20% for the patients that showed more than and equal to 35 and the HEgrade 4. These results are only possible if the time interval of treatment provision and diseasediagnosis is less than 2 weeks. It indicates that the implementation of intervention is effectivefor the improvement of patients with less severe liver disorder. The findings are similar towhat Fujiwara et al. (2008) suggested. Thus, the introduction of corticosteroids at an earlystage is possible to increase the survival rate for the mild liver disorder due to alcohol. Inchronic cases, corticosteroids do not improve the symptoms. However, there is a markeddecrease in the treatment period.

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Term
Winter
Professor
Patricia Chatman
Tags
Hepatology, liver disorder

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