A211Exercise1

# So the only possible combination to make up oranges

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as an allele donor. So, the only possible combination to make up Orange’s genotype would be Billie Jean’s 11 and Mike Johnson’s 12. Mike Johnson has CSF1PO allele 14, the FGA allele 20, the THO1 allele 7, the TPOX allele 6, the VWA allele 13, the D3S1358 allele 19, the D5S818 allele 12, the D7S820 allele 8, the D8S1179 allele 17, the D13S317 allele 8, the D16S539 allele 11, the D18S81 allele 15, and the D21S11 allele 31.2, thus proving that he is Orange’s father, not Jerry Whiteheart. 11

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A211 Name:___Jane Hall_________________ 2c. Given your analysis in question 2b., calculate the probability of finding an individual in the appropriate reference population (African American or Hispanic) who carries all of the required alleles at these 13 markers (those that the father must have contributed to his daughter). Don’t forget to account for any cases where the father might have contributed either allele to the daughter at a particular marker. SHOW YOUR MATH. (6 points). CSF1PO 14 (0.00714)* FGA 20 (0.08929)* THO1 7 (0.27857)* TPOX 6 (0.00357)* VWA 13? (0.00775)* D3S1358 19 (0.00714)* D5S818 12 (0.35000)* D7S820 8 (0.12143)* D8S1179 17 (0.00714)* D13S317 8 (0.12143)* D16S539 11 (0.26071)* D18S81 15 (0.18929)* D21S11 31.2 (0.11071)= 0.0000000000000000070631 probability * If Mike Johnson is Hispanic, he is not supposed to have the 13 allele? 12
A211 Name:___Jane Hall_________________ 2d. Given your analysis in question 2c., and the estimate that there are currently approximately 24,000,000 African Americans in the US and approximately 23,000,000 Hispanic people in the US, calculate the number of people you would expect to find randomly in the population (either the African American or Hispanic population – whichever is the appropriate one) with the necessary alleles to be Orange’s father. SHOW YOUR MATH. (2 points). 0.0000000000000000070631*23,000,000= 0.0000000001624513 people 2e. Given your calculations in 2d., write an explanation to the producers of the show about your confidence that one of these men (Johnson or Whiteheart) is indeed the father of Orange. (2 points) Given the fact that the genotype works out so well in Mike Johnson’s favor plus the fact that only 0.0000000001624513 Hispanic people can have the necessary alleles to be Orange’s father, it is safe to say that there could be no other person other than Mike Johnson who could be the father. 13
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