4 INHIBITORS Generic Brand Common doses Max doses per day Sitagliptin Januvia

4 inhibitors generic brand common doses max doses per

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4) INHIBITORS GenericBrandCommon dosesMax doses per daySitagliptinJanuvia100 mg daily100 mgSaxagliptinOnglyza5 mg daily 5 mgLinagliptinTradjenta5 mg daily5 mgAlogliptinNesina25 mg daily25 mg
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DIPEPTIDYL PEPTIDASE-4 (DPP-4) INHIBITORSHow do they work?Inhibits dipeptidyl peptidase-4Increase insulin synthesis and releaseDecrease glucagon release, decrease hepatic glucose productionIncretin enhancers Indicated for Type 2 DM
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WARNINGS AND PRECAUTIONS Januvia® (sitagliptin)CrCl 30-50 mL/min:50mg/dayCrCl <30: 25 mg/day Onglyza® (saxagliptin)Elderly: 2.5 mg/dayCrCl <50 mL/min: 2.5 mg/dayNesina® (alogliptin)CrCl 30-59 mL/min: 12.5 mg/dayCrCl <30 mL/min: 6.25 mg/day
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SIDE EFFECTSNasopharyngitisUpper Respiratory tract infectionsUrinary tract infectionsHeadachePeripheral edemaRashHypoglycemiaWeight neutral
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PATIENT COUNSELING Take once daily in the morning, with or without foodIf there is trouble breathing or any kind of rash, patient should see the doctor at onceIf patient has severe stomach pain that does not go away, with or without vomiting, patient should go to the doctor
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Sodium Glucose Co-transporter-2 inhibitorsGenericBrandCommon dosesMax doses per dayCanagliflozinInvokana100 mg daily300 mg dailyDapagliflozinFarxiga5 mg daily10 mg dailyEmpagliflozinJardiance10 mg daily25 mg daily
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How do they work?Reabsorption of filtered glucose from the tubular lumen Lowers the renal threshold for glucoseIncreases urinary glucose excretionIndicated for Type 2 DM
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CONTRAINDICATIONS AND WARNINGS ContraindicationsSevere renal impairment (CrCl < 30 ml/min)End stage renal diseaseDialysis WarningsPregnancy Category C
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SIDE EFFECTSFemale genital mycotic infectionsUrinary tract infectionsHyperkalemiaIncrease in urinationRenal insufficiency HypovolemiaHypotensionIncrease in thirstHypoglycemia
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COMBINATION PRODUCTSGENERIC (WITH METFORMIN)BRANDGlipizideMetaglipGlyburideGlucovancePioglitazoneActoplus Met, Actoplus Met XRRosiglitazoneAvandametSitagliptinJanumet, Janumet XRSaxagliptinKombiglyze XRLinagliptinJentaduetoRepaglinide PrandiMetAlogliptinKazano
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COMBINATION PRODUCTS GENERIC (WITH SULFONYLUREAS)BRANDGlimepiride + PioglitazoneDuetactGlimepiride + RosiglitazoneAvandaryl
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COMBINATION PRODUCTS GENERIC (WITH TZD’S)BRANDPioglitazone + AlogliptinOseni
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COMBINATION PRODUCTSBRAND (WITH DPP-4’S)GENERICSitagliptin + SimvastatinJuvisyncLinagliptin + EmpagliflozinGlyxambi
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