A level over 40 microgramsdl indicates that adrenarche has begun PREMATURE

A level over 40 microgramsdl indicates that

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A level over 40 micrograms/dl indicates that adrenarche has begun
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PREMATURE ADRENARCHE CLINICAL DIAGNOSIS: PATHOPHYSIOLOGY: LABS Differential Benign premature adrenarche Tumors (e.g., androgen-secreting tumors in the gonads or adrenals) Congenital disorders (e.g., CAH, McCune-Albright syndrome) Central precocious puberty Exogenous androgen exposure
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PREMATURE ADRENARCHE MANAGEMENT GnRH agonists remain the gold standard for central precocious puberty, usually stopped at 11 years to optimize for height outcomes Surgical removal of any tumors that could be leading to precocious puberty
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PREMATURE ADRENARCHE PROGNOSIS 50% will undergo puberty appropriately with normal fertility Some 20% of affected girls develop clinically significant ovarian hyperandrogenism as adults (e.g., PCOS)
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THE TANNER STAGES OF PUBERTAL DEVELOPMENT IN BOYS AND IN GIRLS PUBERTY CONSISTS OF A SERIES OF PREDICTABLE EVENTS RELATED TO THE DEVELOPMENT OF SECONDARY SEX CHARACTERISTICS
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THE TANNER STAGES OF PUBERTAL DEVELOPMENT IN BOYS AND IN GIRLS PUBERTY CONSISTS OF A SERIES OF PREDICTABLE EVENTS RELATED TO THE DEVELOPMENT OF SECONDARY SEX CHARACTERISTICS
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PREMATURE GONADARCHE CLINICAL DIAGNOSIS Precocious puberty may manifest with either development of all the secondary sexual features or occasionally as isolated premature thelarche, adrenarche, or menarche Central precocious puberty: Premature sexual development typically follows the normal pattern of puberty, except that it is early Peripheral precocious puberty: may not follow the normal developmental pattern; may exhibit possible features of underlying condition (e.g., café-au-lait spots in neurofibromatosis, testicular mass in Leydig cell tumour)
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  • Precocious puberty

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