Must not interfere with the integrity of the shell (materials with high level of free water, that can be absorbed by gelatin causing it to soften and distort). The volume of the unit dose must not exceed the size of capsule available.
Capsule Filling Type of Material for Filling Dry solids: Powders, Pellets, Granules, Tablets Semisolids: • Thermosoftening mixtures (during filling are in the molten state and fluid enough to be pumped and filled. On standing solidification happens. E.g. PEG 4000, solid fat. • Thixotropic mixtures: thin with low viscosity upon shearing by mixing and form hard mass with high viscosity upon standing when shearing ceases. During filling they are fluid and semisolid during shelf life. • Pastes. • Liquids: Non-aqueous liquids: requires sealing by applying gelatin solution at the cap-body joint to form sealing gelatin band upon drying. If not sealed leakage at the joint will happen during handling. Sealing also reduces oxygen permeation into the content, protecting them from oxidation.
Bench-scale filling: Used for small quantities of capsules ranging from 50 to 10 000 in number. Usually in community pharmacies, hospital pharmacies or even in the industry for special prescriptions or trials. Filling of Powder Formulations Bench – Scale filling
Many capsule filling machines may be used for this purpose “Labocaps and Feton ”. They consist of sets of plastic plates with predrilled holes to take from 30-100 capsules of a specific size. Empty capsules are fed into the device either manually or with a simple loading device. Filling of Powder Formulations Bench – Scale filling
Filling of Powder Formulations Bench – Scale filling The bodies are locked in their plate by means of a screw and the caps in their plate are removed. The powder is placed onto the surface of the body plate and is spread with a spatula so that it is filled into the bodies. The cap plate is then repositioned over the body one and the capsules are rejoined using manual pressure. The uniformity of fill weight is very dependent upon good flow properties of the powder.
Filling of Powder Formulations