Benzoyl Peroxide Mechanism Benzoyl peroxide is a topical medication with both

Benzoyl peroxide mechanism benzoyl peroxide is a

This preview shows page 17 - 23 out of 57 pages.

Benzoyl Peroxide Mechanism: Benzoyl peroxide is a topical medication with both antibacterial and comedolytic properties Acts via the generation of free radicals that oxidize proteins in the P acnes cell wall Available forms: Available as a prescription and over-the-counter, as well as in combinations with topical antibiotics Cream, lotion, gel, or wash Common Adverse Effects: Bleaching of hair, colored fabric, or carpet May irritate skin; discontinue if severe 17
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Topical Antibiotics Mechanism Reduce the number of P. acnes and reduce inflammation in inflammatory acne Available forms: Erythromycin 2% (solution, gel) Clindamycin 1% (lotion, solution, gel, foam) Common Adverse Effects: Topical acne treatments are often irritating and can cause dry skin When using retinoids or benzoyl peroxide, consider beginning on alternate days Use a moisturizer to reduce their irritancy Additional considerations: Often used with benzoyl peroxide (versus monotherapy) to prevent the development of antibiotic resistance in the treatment of mild-to-moderate acne 18
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19 Acne Treatment: Patient education Patient education and setting expectations are important components of effective acne treatment Physician and patient should develop a therapeutic regimen with the highest likelihood of adherence Acne treatment targets new lesions, not present ones Lack of adherence is the most common cause of treatment failure Patients will often stop their topical treatments too early without improvement in their acne Topical agents take 2-3 months to see effect Therapy should be continued for at least 8 weeks before a treatment response can be accurately evaluated
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20 Acne Treatment: Patient education Many patients can be non-adherent to topical treatments due to adverse effects including skin dryness, peeling, redness, itching, burning, and stinging Acne-affected skin can be deficient in ceramides, which play an important role in maintaining the skin barrier and preserving its ability to prevent moisture loss Daily use of ceramide-containing moisturizers may improve skin dryness and irritation by repairing and maintaining the skin barrier, leading to improved adherence
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21 Acne Treatment: Patient education Patients should use only the prescribed medications and avoid potentially drying over-the-counter products, such as astringents, harsh cleansers or antibacterial soaps, as they are ineffective for acne and potentially drying Overaggressive washing and the use of particulate abrasive scrubs often exacerbates acne and should be avoided Cosmetics are often labeled as “non-comedogenic” or “oil-free” if they do not cause or exacerbate acne There is some evidence to suggest that diet contributes to acne Low glycemic load diets may improve acne by reducing androgen-induced sebaceous gland activity and keratinocyte growth associated with increased insulin and IGF-1 levels
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22 Case Two Ryan Townsend
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  • Spring '09
  • Hurley
  • Anatomy, acne

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