25 3 075 Method for using displacement value Required to prepare for 8

Glycerin Suppositories Gelatin dissolves in hot water, forming a solution which sets to a jelly. This fact is used to convert glycerin into solid Corm for use as suppository. A suitable gelatin jelly is also used as a base for other medicaments besides glycerin. A gelatin base is incompatible with many of the substances prescribed in suppositories, e.g. tannic acid, ferric chloride, gallic acid and for this and other reasons; it is less frequently used than cacao butter. Glycerin suppositories containing ichthammol become insoluble on storage. I. Glycerin Suppository B.P.. R/ Gelatin 14 g Glycerin 70 g Water QS to 100g This is a suitable base for medicated suppositories containing solid medicaments or not more than 20 per cent of semisolid or liquid medicaments. With more than this , the mass becomes too soft.

Experiment – 11 Aim:- Preparation of glycerogelatin base suppositories Rx Gelatin 14 g Glycerin 70 g Water QS to 100g Equipments Required:- Mortar and pestle, Porcelain crucible, water-bath, 2 g x 6 mold Chemicals: Gelatin 84g, Glycerin 420 g, water 96 ml. Procedure: 1. Calculate for 6 supp., that is the amount of Gelatin = 6 x 14 = 84 g. 2. Weigh the required amount of gelatin and soak it in enough water until thoroughly softened. 3. Put the soaked gelatin on the calculated amount of glycerin previously weighed in a tared crucible and on a water bath until gelatin dissolves and a constant weight is obtained. 4. During evaporation the liquid mass should be only gently stirred, rapid stirring produce air bubbles which may appear in the finished suppositories. 5. Remove any skin formed on the surface before pouring. 6. Pour the mass while still hot, into the holes lubricated with liquid paraffin, do not let the melted mass to overflow.