Chapter 1 Infection

20th century the sciences of molecular biology

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20th century, the sciences of molecular biology, genetics, genomics, and proteomics extended these insights to the molecular level. Genetic advances have reached the point at which it is possible to know not only the genes involved but to understand how they are regulated. The discoveries of penicillin by Fleming in 1929 and of sulfonamides by Domagk in 1935 opened the way to great developments in chemotherapy. These gradually extended from bacterial diseases to fungal, parasitic, and finally viral
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infections. Almost as quickly, virtually all categories of infectious agents developed resistance to all categories of antimicrobics to counter these chemotherapeutic agents. Infectious Agents: The Microbial World Viruses Bacteria Fungi Parasites Microbiology is a science defined by smallness. Its creation was made possible by the invention of the microscope (Gr. micro, small + skop, to look, see), which allowed visualization of structures too small to see with the naked eye. This definition of microbiology as the study of microscopic living forms still holds if one can accept that some organisms can live only in other cells (eg, all viruses and some bacteria) and that others have macroscopic forms (eg, fungal molds, parasitic worms). The relative sizes of some microorganisms are shown in Figure 1–2. Microorganisms are responsible for much of the breakdown and natural recycling of organic material in the environment. Some synthesize nitrogen-containing compounds that contribute to the nutrition of living things that lack this ability; others (oceanic algae) contribute to the atmosphere by producing oxygen through photosynthesis. Because microorganisms have an astounding range of metabolic and energy-yielding abilities, some can exist under conditions that are lethal to other life forms. For example, some bacteria can oxidize inorganic compounds such as sulfur and ammonium ions to generate energy, and some can survive and multiply in hot springs at temperatures higher than 75°C. Some microbial species have adapted to a symbiotic relationship with higher forms of life. For example, bacteria that can fix atmospheric nitrogen colonize root systems of legumes and of a few trees such as alders and provide the plants with their nitrogen requirements. When these plants die or are plowed under, the fertility of the soil is enhanced by nitrogenous compounds originally derived from the metabolism of the bacteria. Ruminants can use grasses as their prime source of nutrition, because the abundant flora of anaerobic bacteria in the rumen break down cellulose and other plant compounds to usable carbohydrates and amino acids and synthesize essential nutrients including some amino acids and vitamins. These few examples illustrate the protean nature of microbial life and their essential place in our ecosystem.
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