Radicals are also known as Reactive Oxygen Species ROS Highly reactive Produced

Radicals are also known as reactive oxygen species

This preview shows page 4 - 7 out of 16 pages.

Radicals are also known as Reactive Oxygen Species (ROS) Highly reactive Produced by all aerobic cells. Play a role in diseases of aging and aging. Oxidative stress, aging, and diseases. Liguori I, Russo G, Curcio F, Bulli G, Aran L, DellaFMorte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P. Clin Interv Aging. 2018 Apr 26;13:757F772. doi: 10.2147/CIA.S158513. eCollection 2018. Review. II) Free Radical Theory of Aging Free radical theory of aging = oxidative stress theory of aging Aging is due to the buildup of oxidative damage to molecules (lipids, DNA, proteins, carbohydrates) via ROS . 4
Image of page 4
²0–01– [email protected] J Damaging to phospholipids (cellular membranes) and proteins Damaging to proteins Endogenous Types of ROS Superoxide anion (O 2 ) Very reactive because it wants to get rid of extra electron Hydrogen peroxide (H 2 O 2 ) is not a free radical but can form the highly reactive hydroxyl (OH ) radical or can form water: H 2 O 2 in the presence of chloride and myeloperoxidase can form hypochlorous acid (will cause damage to lipids, DNA, proteins etc.): Nitric oxide (NO) and oxygen may interact to form peroxynitrite (ONOO F ). Oxidative stress, aging, and diseases. Liguori I, Russo G, Curcio F, Bulli G, Aran L, DellaFMorte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P. Clin Interv Aging. 2018 Apr 26;13:757F772. doi: 10.2147/CIA.S158513. eCollection 2018. Review. Exogenous Sources of ROS Pollution Heavy metals Tobacco/Alcohol Industrial solvents Certain drugs Radiation FREE RADICALS Oxidative stress, aging, and diseases. Liguori I, Russo G, Curcio F, Bulli G, Aran L, DellaFMorte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P. Clin Interv Aging. 2018 Apr 26;13:757F772. doi: 10.2147/CIA.S158513. eCollection 2018. Review.
Image of page 5
²0–01– [email protected] @ Modifications Due to ROS Modifications can happen to: Carbohydrates Lipids Proteins DNA These modifications can be used to assess oxidative stress . Oxidative stress, aging, and diseases. Liguori I, Russo G, Curcio F, Bulli G, Aran L, DellaFMorte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P. Clin Interv Aging. 2018 Apr 26;13:757F772. doi: 10.2147/CIA.S158513. eCollection 2018. Review. Types of Biomarkers Indicating ROS Damage to proteins : protein carbonyls (PC) Damage to lipids : lipid peroxidation Malondialdehyde (MDA) Isoprostanes (F 2 HIsoPs) Damage to carbohydrates : Advanced glycation endHproducts (AGEs) Damage to DNA : 8 -o x o -7, 8 dihydro-guanine (8-oxoGuo) Oxidative stress, aging, and diseases. Liguori I, Russo G, Curcio F, Bulli G, Aran L, DellaFMorte D, Gargiulo G, Testa G, Cacciatore F,
Image of page 6
Image of page 7

You've reached the end of your free preview.

Want to read all 16 pages?

  • Fall '19
  • jay johnson
  • Free-radical theory, reactive oxygen species, oxidative stress, Russo G, Bulli G

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern

Stuck? We have tutors online 24/7 who can help you get unstuck.
A+ icon
Ask Expert Tutors You can ask You can ask You can ask (will expire )
Answers in as fast as 15 minutes