Chapter 5 Stem Cells Outline Stem cells proliferative undifferentiated

Chapter 5 stem cells outline stem cells proliferative

This preview shows page 7 - 12 out of 12 pages.

Chapter 5 Stem Cells Outline Stem cells: proliferative undifferentiated, unlimited self-renewal renew themselves and produce progenitor cells Different types Microenvironment: stem cell niche Growth: one stem cell two stem cells Differentiation: one stem cell one stem cell + one progenitor cell Death? (Deprivation): one stem cell two progenitor cells
Image of page 7

Subscribe to view the full document.

Figure 5.1 The stem cell concept How to maintain a pool of stem cells
Image of page 8
Figure 5.2 An example of the maturational series of stem cells Three types of stem cell pools Totipotent Pluripotent A variety of multipotent and committed stems cells during development and in adults Totipotent: all cell lineages Pluripotent: all cell types of the embryo
Image of page 9

Subscribe to view the full document.

Figure 5.3 Blood-forming (hematopoietic) stem cells (HSCs) Proof of stem cells --- bone marrow transplant
Image of page 10
Figure 5.4 To divide or not to divide: an overview of stem cell regulatory mechanisms A variety of ways to keep stem cells dividing and undifferentiated E xtrinsic factors – physical contact and chemical (or ligand) dependent I ntrinsic factors – asymmetrical distribution of determinants - changes in gene expression E E E E E I I
Image of page 11

Subscribe to view the full document.

Figure 5.5 Establishment of the inner cell mass (the ICM, which will become the embryo) in the mouse blastocyst Stem cells in mammalian embryo Totipotent – all cell types from the fertilized egg including support cells Pluripotent – all cell types of the body Totipotent Inner Cell Mass - pluripotent Embryonic Stem Cells (ESC) Trophectoderm (trophoblast) (extraembryonic) Primitive endoderm (extraembryonic) Epiblast (embryo)
Image of page 12

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern

Ask Expert Tutors You can ask 0 bonus questions You can ask 0 questions (0 expire soon) You can ask 0 questions (will expire )
Answers in as fast as 15 minutes