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Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest. REFERENCES 1. Adriaens PA, De Boever JA, Loesche WJ. Bacterial invasion in root cementum and radicular dentin of periodontally diseased teeth in humans. A reservoir of periodontopathic bacteria. J Periodontol 1988;59:222-30. 2. Rams TE, Slots J. Local delivery of antimicrobial agents in the periodontal pocket. Periodontol 2000 1996;10:139-59. 3. Golub LM, Lee HM, Lehrer G, Nemiroff A, McNamara TF, Kaplan R, et al. Minocycline reduces gingival collagenolytic activity during diabetes. Preliminary observations and a proposed new mechanism of action. J Periodontal Res 1983;18:516-26. 4. van Winkelhoff AJ, Rams TE, Slots J. Systemic antibiotic therapy in periodontics. Periodontol 2000 1996;10:45-78. 5. Dodwad V, Vaish S, Mahajan A, Chhokra M. Local drug delivery in periodontics: A strategic intervention. Int J Pharm Pharm Sci 2012;4:30-4. 6. Goodson JM, Haffajee A, Socransky SS. Periodontal therapy by local delivery of tetracycline. J Clin Periodontol 1979;6:83-92. 7. Vedamurthy M. Soft tissue augmentation – Use of hyaluronic acid as dermal filler. Indian J Dermatol Venereol Leprol 2004;70:383-7. 8. Bartold PM, Page RC. Hyaluronic acid synthesized by fibroblasts cultured from normal and chronically inflamed human gingivae. Coll Relat Res 1986;6:365-77. 9. Moseley R, Waddington RJ, Embery G. Hyaluronan and its potential role in periodontal healing. Dent Update 2002;29:144-8. 10. Adams ME, Atkinson MH, Lussier AJ, Schulz JI, Siminovitch KA, Wade JP, et al. The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of osteoarthritis of the knee: A Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone. Osteoarthritis Cartilage 1995;3:213-25. 11. Neumayer T, Prinz A, Findl O. Effect of a new cohesive ophthalmic viscosurgical device on corneal protection and intraocular pressure in small-incision cataract surgery. J Cataract Refract Surg 2008;34:1362-6. 12. Matsuno H, Yudoh K, Kondo M, Goto M, Kimura T. Biochemical effect of intra-articular injections of high molecular weight hyaluronate in rheumatoid arthritis patients. Inflamm Res 1999;48:154-9. 13. Johannsen A, Tellefsen M, Wikesjö U, Johannsen G. Local delivery [Downloaded free from on Friday, September 15, 2017, IP: 36.79.172.174]
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Shah, et al .: Hyaluronan as local drug delivery 8 Journal of Indian Society of Periodontology of hyaluronan as an adjunct to scaling and root planing in the treatment of chronic periodontitis. J Periodontol 2009;80:1493-7. 14. Dahiya P, Kamal R. Hyaluronic acid: A boon in periodontal therapy. N Am J Med Sci 2013;5:309-15. 15. Jentsch H, Pomowski R, Kundt G, Göcke R. Treatment of gingivitis with hyaluronan. J Clin Periodontol 2003;30:159-64. 16. Bertl K, Bruckmann C, Isberg PE, Klinge B, Gotfredsen K, Stavropoulos A. Hyaluronan in non-surgical and surgical periodontal therapy: A systematic review. J Clin Periodontol 2015;42:236-46.
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  • Fall '19
  • Statistical significance, SRP, Periodontitis, Hyaluronan

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