clavulanate extends the action of amoxicillin by impeding beta lactamase

Clavulanate extends the action of amoxicillin by

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clavulanate extends the action of amoxicillin by impeding beta-lactamase producing bacteria (Micromedex, 2018). The half-life of amoxicillin is 0.7-1.4 hours and clavulanic acid is 0.8-1.4 hours (Micromedex, 2018). It is partially metabolized by the liver, and excretion is completed 30% by the liver and 70% unchanged in urine (Woo & Robinson, 2016). Common side effects include: diarrhea, rash, nausea, mycosis, vomiting, candidiasis, and vaginitis (Micromedex, 2018). Pregnancy category B signifying no evidence of harm to the fetus and minimal risk to the infant when used during breastfeeding (Micromedex, 2017). Contraindicated in those allergic to penicillin, cephalosporins, or carbapenems, individuals with severe renal impairment or requiring hemodialysis, concurrent use with BCG and typhoid live vaccines (Micromedex, 2018). Increased risk of diarrhea and clostridium difficile associated diarrhea (Micromedex, 2018). Risk for bacterial or fungal super infections (Micromedex, 2018).
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Caution should be used in persons with hepatic impairment (Micromedex, 2018). There are no black box warnings listed for Augmentin (Micromedex, 2018). 4. Would this treatment vary if Mr. JD was a 10-year-old 78 lb child? Include the class of the medication, mechanism of action, dosing, route, the half-life; how it is metabolized in and eliminated from the body; and contraindications and black box warnings. Amoxicillin 45mg/kg/day (1592mg) orally in two divided doses for 10 days is the first line of therapy for sinusitis in adolescents (Woo & Robinson, 2017). Classification of amoxicillin is a aminopenicillin antibiotic and the half-life is 1-2 hours in children (Micromedex, 2018). Mechanism of action entails amoxicillin binding to penicillin- binding proteins inhibiting the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls (Micromedex, 2018). It is partially metabolized by the liver, and excretion is completed 30% by the liver and 70% unchanged in urine (Woo & Robinson, 2016). Most common side effects: diarrhea, rash, and nausea (Drugs.com, 2018). Contraindicated in those allergic to penicillin, cephalosporins, and imipenem, individuals with severe renal impairment or requiring hemodialysis, concurrent use with BCG and typhoid live vaccines (Micromedex, 2018). May take without regard to meals (Drugs.com, 2018). Increased risk of clostridium difficile associated diarrhea (Micromedex, 2018). There are no black box warnings listed for amoxicillin (Drugs.com, 2018).
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  • Fall '16
  • Sinusitis, Buttaro

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