ORBilateral Subcapsular Orchidectomy:This is an operation where the functioning part ofthe testicles is removed. This is normally done by taking out the centre of the testicles,leaving the testicles themselves behind but reduced in size. Sometimes, instead of thisoperation the testicles are removed completely. Your surgeon will discuss the surgical optionswith you. These operations are usually straightforward but there will be some pain ordiscomfort in the scrotum afterwards. There may also be some swelling and bruising in thescrotum that takes a couple of weeks to subside, and as with any surgical operation aninfection can occur in the wound.CelecoxibPage 1Version 2 (June 2005)
STAMPEDEThe celecoxib tablets are taken twice a day and will continue for a maximum of 1 year. Theywill only be stopped if your cancer shows signs of not responding to the treatment or if youand your doctor decide this is best. Unwanted effects may include stomach discomfort,indigestion, abdominal pain and flatulence, fluid retention, difficulty sleeping, sinusitis or asore throat, a rash and a small increased risk of a cardiovascular event (see below).Recently, information from three long-term studies of celecoxib has become available. In thefirst study, which was aimed at preventing rather than treating cancer, a small increased riskof heart attacks, strokes, and/or deaths resulting from heart or blood vessel disease wasreported among people taking celecoxib. Approximately 1 in 100 patients in this study onplacebo treatment had one of these serious events. In contrast, between 2 and 3 in 100patients taking celecoxib (between 400 and 800 mg daily) had one of these serious events.Another clinical cancer prevention study found no increased risks in patients taking celecoxib400 mg daily. The third study, an Alzheimer's disease prevention study, did not find increasedrisks with celecoxib.