The newest group of antidepressant drugs
•
Specifically block the reuptake of 5HT, with little to no known
effect on NE
•
Do not have many adverse effects associated with TCAs and
MAOIs
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Selective Serotonin Reuptake Inhibitors (cont.)•Actions–Inhibits CNS neuronal reuptake of serotonin with little effect on norepinephrine and little affinity for cholinergic, histaminic, or alpha-adrenergic sites•Indications–Depression, OCDs, panic attacks, bulimia, PMDD, posttraumatic stress disorders, social phobias, social anxiety disorders
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Selective Serotonin Reuptake Inhibitors
(cont.)
•
Pharmacokinetics
–
Absorbed from the GI tract
–
Metabolized in the liver
–
Associated with congenital abnormalities
•
Contraindications
–
Known allergy, pregnancy, lactation, impaired renal
function or hepatic function
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Selective Serotonin Reuptake Inhibitors (cont.) •Adverse Reactions–Headache, drowsiness, dizziness, insomnia, anxiety, tremor, agitation•Drug-to-Drug Interactions–MAOIs–TCAs increase of therapeutic and toxic effect
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Prototype SSRI Agent
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Prototype SSRI Agent (Continued)
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Nursing Considerations for SSRI
Antidepressant Agents
•
Assessment: History and Physical Exam
•
Nursing Diagnosis
•
Implementation
•
Evaluation
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Miscellaneous Antidepressants
•
Bupropion (
Wellbutrin, Zyban
)
•
Mirtazapine (
Remeron
)
•
Nefazodone (
Serzone
)
•
Trazodone (
Desyrel
)
•
Venlafaxine (
Effexor
)
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Use of Antidepressant Agents Across
the Lifespan
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- Summer '16
- Selective serotonin reuptake inhibitor, Antidepressant, Tricyclic antidepressant, Wolters Kluwer Health, Lippincott Williams & Wilkins
