Toxicologia_Fundamental_Repetto_4ª_Edicion_booksmedicos.org.pdf

Los teratógenos más conocidos son la talidomi da la

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Los teratógenos más conocidos son la talidomi- da, la colchicina, el alcohol etílico, causante del síndrome alcohólico fetal , la vitamina A, etc, (véa- se Tabla 7.20). 336 TOXICOLOGÍA FUNDAMENTAL IARC 1 Humano 2A Probable 2B Posible 3 No clasificado 4 No carcinógeno ACGIH A1 Humano A2 Sosp. humano A3 Animal A4 No clasificado A5 No sospechoso EPA A Humano B1 Probable B2 Probable C Posible D No clas. E No carcinógeno MAK IIIA1 Humano IIIA2 Probable IIIB Posible EU 1 Humano 2 Probable 3 Posible EP 1 Humano 2 Probable 3 Posible E Lista A: 1 Lista D:2 Lista C: Lista D: Lista E: Lista E: Humano Probable Mutágenos Mutágenos Tox. Reprod. Tox. Reprod. Cat. 1 Cat. 2 Cat. 1 Cat.1 De: E. de la Peña et al. (2006). Tabla 7.18. Clasificación de las sustancias conforme a su potencialidad carcinogénica, según distintos organismos y normativas A. Formación liberación de Gametos B. Fertilización. Concepción, Transporte del zigoto C. Implantación. Organogénesis D. Desarrollo fetal. Final de la preñez E. Nacimiento. Desarrollo postnatal F. Maduración sexual Tabla 7.19. Reproducción y desarrollo. Momentos más sensibles a los tóxicos
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BIBLIOGRAFÍA Agencia Internacional de Investigaciones sobre el Cán- cer (Lyon): <http://www .iar c .fr > Andrade-Ribeiro A, Pacheco-Ferreira A, Nobreg CL, Mendes A. Disruptores endocrinos: problema poten- cial para la salud pública y el medio ambiente. Rev. Biomed, Brasil, 2006; 17:146-150. Anónimo. Report of Multiple Chemical Sensitivities (MCS) Workshop: International Programme on Che- mical Safety (IPCS)/German Workshop on Multiple Chemical Sensitivities. Berlin, Germany, 21-23 February 1996. Int. Arch. Occup. Environ Health . 1997; 69:224-226 Anniko M. Principies in cochlear toxicity. Arch To xicol. Sup. 8. Berlín: Springer-Verlag, 1985. Ballescá JL. III Encuentro Iberoamericano de Androlo- gía. Cuba, 2006. Banco de Datos de Disruptores Endocrinos, FDA, EEUU: http://edkb .fda.g o v/ Balazs T. Cardiac toxicology. 3 volúmenes. Boca Ratón: CRC Press, 19 8 1. Ballantyne B, Marrs T, Turner P. General and applied toxicology. Wimblendon: Macmillan Press, 1993. Barratt MD. Quantitative structure-activity relationships for skin corrosivity. ATLA, 1995; 23(2):243-455. Barreiro R, Quintela M, Ruíz JM. TBT e imposex en Galicia: efectos en un gasterópodo marino. Ecosiste- mas, 2004, 13, 1-17. Bennetts HW, Underwood EJ, Sheir FL. A specific bre- eding problem of sheep on subterranean clover pas- tures in Western Australia. Austral Vet J. 1946, 22:2- 12 Berenguer MJ, Martí MC. Ambientes cerrados: calidad del aire. NTP-243 . I.N.S.H.T, Madrid (1989) Berndt WO. The role of transport in chemical nephroto- xicity. Toxicologic Pathology. 1998; 26, 1:52-57. Bronaugh T, Maibach H. Percutaneous absorption. New York: Marcel Dekker Inc., 1985. Cavanh JB. Peripheral neuropathy caused by Chemical agents, En: CRC Critical Reviews in Toxicology, Ohio: C.R.C. Press, 1973. Cohen GM. Target organ toxicity. Vols. 1 y 11. Boca Ratón: CRC Press, 1986.
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