When given concurrently with macrolide antibiotics methylprednisolone clearance

When given concurrently with macrolide antibiotics

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When given concurrently with macrolide antibiotics, methylprednisolone clearance is reduced, so a smaller dose of methylprednisolone is needed. IM administration does not affectclearance of the drug. Changing the dose to twice-daily dosing is not recommended. Stopping the drug abruptly is not recommended.
DIF:Cognitive Level: Applying (Application)REF:579
7.A patient is being tapered from long-term therapy with prednisolone and reports weight loss and fatigue. The primary care NP should counsel this patient to:
DIF:Cognitive Level: Applying (Application)REF:578

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