Barbiturates Pharmacokinetics Barbiturates Pharmacokinetics Well absorbed

Barbiturates pharmacokinetics barbiturates

This preview shows page 18 - 25 out of 30 pages.

Barbiturates: Pharmacokinetics Barbiturates: Pharmacokinetics Well absorbed Reaching peak in 20 – 60 minutes Metabolized in the liver Excreted in the urine Lipid soluble, pass to placenta
Image of page 18
Barbiturates: Contraindications and Cautions Barbiturates: Contraindications and Cautions Allergy to any barbiturate Previous history of addiction to sedative–hypnotic drugs Latent or manifest porphyria (accumulation of chemical substance) – can exacerbate Marked hepatic impairment or nephritis Respiratory distress or severe respiratory dysfunction- CNS depression makes it worse Pregnancy – congenital abn. Caution in people with acute or chronic pain – can mask symptoms, with seizures (abrupt withdrawal can exacerbate), and with hepatic/cardiac/respiratory diseases.
Image of page 19
Barbiturates: Adverse Reactions Barbiturates: Adverse Reactions CNS Depression Physical Dependency Drowsiness Somnolence Lethargy Ataxia Vertigo Nausea Vomiting Constipation Hangover Anxiety Hallucinations
Image of page 20
Barbiturates: Drug-to-Drug Interactions Barbiturates: Drug-to-Drug Interactions Increase CNS depression when given with alcohol, antihistamines, and other tranquilizers Altered response to phenytoin MAO cause increase serum levels and effect Decrease effectiveness of the following drugs: anticoagulants, digoxin, tricyclic antidepressants, corticosteroids, oral contraceptive
Image of page 21
Nursing Considerations for Barbiturates Nursing Considerations for Barbiturates Assessment: History and Physical Exam Nursing Diagnosis- don’t admin intra-arterially, don’t mix, stand by – life support equipment Implementation Evaluation
Image of page 22
Prototype Barbiturates Agent Prototype Barbiturates Agent
Image of page 23
Image of page 24
Image of page 25

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture