Orange which has a sharp peak followed by a broad

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(orange), which has a sharp peak followed by a broad region of enrichment; medium size broad peaks, as shown for histone H3 trimethylated at lysine 36 (H3K36me3; green), which is associated with transcription elongation over the gene; or large domains, as shown for histone H3 trimethylated at lysine 27 (H3K27me3; blue), which is a repressive mark that is indicative of Polycomb-mediated silencing. BPIL2, bactericidal/permeabilityincreasing protein-like 2; FBXO7, F box only 7; NPC1, Niemann-Pick disease, type C1; Pros35, proteasome 35 kDa subunit; SYN3, synapsin III. Data for part b are from Ref. 25.
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Typical example of histone methylation patterns at active and inactive genes shown as custom tracks on the UCSC genome browser. Barski et al. (2007) Cell 129, 823
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ZNF gene repeats are marked by high levels of H3K9me3 and H4K20me3. Correlation of Histone Methylation Patterns with Chromosomal Features Barski et al. (2007) Cell 129, 823
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Nicole F. Mathon & Alison C. Lloyd Nature Reviews Cancer 1, 203-213 (December 2001) Cell Senescence
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A stepwise model for the formation of SAHF in senescent human cells. Zhang R et al. Mol. Cell. Biol. 2007;27:2343-2358
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Confocal images of indirect immunofluorescence for H3K9me3 and H3K27me3 in growing and Ras-senescent IMR90 cells. Arrows indicate inactive X chromosomes. Chromatin reorganization with senescence Formation of Senescence Associated Heterochromatin Foci (SAHFs) Chandra et al. (2012) Mol Cell. 2012 Jul 27;47(2):203-14
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