Drug that inhibit breakdown of incretins DPP 4 inhibitors Drugs that mimic

Drug that inhibit breakdown of incretins dpp 4

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Drug that inhibit breakdown of incretins DPP 4 inhibitors Drugs that mimic action of incretins DPP 4 inhibitors GLP 1 Agonists Incretin enhancers “Incretine” → intestinal secretion of insulin Hormone secreted by small intestine following meal when glucose is elevated Signals pancreas to increase insulin secretion and liver to stop producing glucagon Both actions lower BG Decrease food intake by increasing feeling of satiety Mimetic- GLP 1 Agonist: exenatide (byetta) → enhances inculin secretion in presence of glucose Decreases glucagon secretion Adjunct for T2 taking oral agents Admin SQ 1 hr before breakfast and dinner Not an insulin Hypoglycemia can occur GI distress common
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Alpha glucosidase inhibitors→ slow carb absorption and digestion Inhibts enzyme needed for carb digestion-enzyme that digest starches in small intest Decreases postprandial (after meal) glucose levels Admin w/ 1st bite of meal Adverse effects GI (flatulence, bloating, diarrhea) hepatotoxicity→ contraindication w/ cirrhosis or IBD Use oral glucose tab for hypoglycemia Ex: acarbose (precose), miglitol (glyset) * For all prototype drugs, you should know mechanism of action, Basic pharmacokinetic features (e.g., is the drug given p.o. or IV), therapeutic uses, Major adverse effects/contraindications, contraindications, cross-sensitivity for antibiotics (if applicable), pertinent patient teaching information, drug levels (i.e., peak & trough) if indicated. Also know if it interacts with food, and how it does, and how to minimize side effects, and any Patient teaching/nursing interventions/know how it works to relieve symptoms; pregnancy risk USE YOUR ADAMS AND ATI BOOK AND ATI “PHARM MADE EASY”TO HELP YOU STUDY IMPORTANT FACTS ABOUT THESE DRUGS Remember: If you know the action of the pharmacologic category, you will be able to answer questions about any drug in that category
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