Question : Carbamazepine has a black box warning recommending testing for the HLA-B*1502 allele in patients with Asian ancestry prior to starting therapy due to: Student Answer: Decreased effectiveness of carbamazepine in treating seizures in Asian patients with the HLA-B*1502 allele Increased risk for drug interactions in Asian patients with the HLA-B*1502 allele Increased risk for Stevens-Johnson syndrome in Asian patients with HLA-B*1502 allele Patients who have the HLA-B*1502 allele being more likely to have a resistance to carbamazepine Points Received: 0 of 2.5 Comments : Question 7 . Question : The major reason for not crushing a sustained release capsule is that, if crushed, the coated beads of the drugs could possibly result in: Student Answer: Disintegration Toxicity Malabsorption Deterioration Points Received: 2.5 of 2.5 Comments
: Question 8 . Question : The role of the nurse practitioner in the use of herbal medication is to: Student Answer: Maintain competence in the prescribing of common herbal remedies. Recommend common OTC herbs to patients. Educate patients and guide them to appropriate sources of care. Encourage patients to not use herbal therapy due to the documented dangers. Points Received: 2.5 of 2.5 Comments : Question 9 . Question : The time required for the amount of drug in the body to decrease by 50% is called: Student Answer: Steady state Half-life Phase II metabolism Reduced bioavailability time Points Received: 2.5 of 2.5 Comments : Question 10 . Question : The angiotensin converting
enzyme (ACE) inhibitor lisinopril is a known teratogen. Teratogens cause Type ____ ADR. Student Answer: A B C D Points Received: 2.5 of 2.5 Comments : Question 11. Question : Genetic polymorphisms account for differences in metabolism, including: Student Answer: Poor metabolizers (PMs) that lack a working enzyme Intermediate metabolizers (IMs) that have one working, wild-type allele and one mutant allele Extensive metabolizers (EMs), with two normally functioning alleles All of the above Points Received: 2.5 of 2.5 Comments : Question 12 . Question : Pharmacokinetic factors that affect prescribing include: Student Answer: Therapeutic index
Minimum effective concentration Bioavailability Ease of titration Points Received: 2.5 of 2.5 Comments : Question 13 . Question : Warfarin resistance may be seen in patients with VCORC1 mutation, leading to: Student Answer: Toxic levels of warfarin building up Decreased response to warfarin Increased risk for significant drug interactions with warfarin Less risk of drug interactions with warfarin Points Received: 2.5 of 2.5 Comments : Question 14 . Question : Patient education regarding prescribed medication includes: Student Answer: Instructions written at the high school reading level Discussion of expected ADRs How to store leftover medication such as antibiotics Verbal instructions
always in English Points Received: 2.5 of 2.5 Comments : Question 15 .
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- Fall '20
- Pharmacology, carbamazepine