Therapeutic effect or mechanism of action are used

therapeutic effect or mechanism of action) are used together to produce
a combined effect, and the outcome is a drug effect greater than either
drug's activity alone. As a result, the patient's hypertension may be
better treated than with a single drug. This does not necessarily reduce
the risk of adverse reactions or increase compliance with the regimen.
Question 24
A home health nurse notes that there have been changes to a patient's oral drug
regimen. The nurse will closely monitor the new drug regimen to
Response
Feedback:
Changes in the drug regimen may cause changes in drug absorption
and thereby decrease the anticipated drug effect. This decrease is due
to the prevention of binding and loss of absorption and overall drug
effectiveness. A change in the drug regimen would not help a nurse to
track the route of metabolism or determine the speed of chelation. If any
adverse effect were to occur as a result of a drug regimen change, it
would not necessarily be immunotoxicity; it could also be nephrotoxicity,
ototoxicity, or cardiotoxicity.
Question 25
A patient has been prescribed an oral drug that is known to have a high first-pass
effect. Which of the following measures has the potential to increase the amount of the
free drug that is available to body cells?
Response
Feedback:
Unlike oral medications, drugs that are given intravenously do not
initially pass through the liver. As a result, the first-pass effect is
mitigated and more of the drug is available to cells. Frequent oral
doses, low protein intake, and administration with food do not reduce
the first-pass effect.
Question 26
An elderly man has been admitted to a residential care facility and the nurse has
conducted a medication reconciliation. The man has taken numerous drugs in the
past, including a course of bicalutamide (Casodex) several years earlier. The nurse
recognizes this drug as being an antiandrogen and is consequently justified in
presuming that the man has a history of what disease?
Response
Feedback:
In male patients, antiandrogens are used to treat prostate cancer.
They are not included in treatment of lymphomas, skin cancer, or
lung cancer.
1 out of 1 points
1 out of 1 points
1 out of 1 points
1 out of 1 points

Question 27
A nurse is caring for a 78-year-old patient with renal insufficiency and chronic heart
failure who is receiving rapid infusions of high-dose furosemide. It will be a priority for
the nurse to monitor for
Response
Feedback:
Ototoxicity can occur with rapid intravenous administration, especially in
patients with poor renal function and in those receiving high doses of
furosemide. Although usually transient, ototoxicity may result in
permanent damage. Rapid infusions of high-dose furosemide would not
place the patient at risk for hepatic encephalopathy. Excessive diuresis
from furosemide can result in dehydration and vascular thrombosis, but
they would not be the priority in this case.
Question 28
A 72-year-old man who is unable to sleep since admission into the hospital is given a
hypnotic medication at 9 p.m. The nurse finds the patient drowsy and confused at 10