Copyright 2017 Wolters Kluwer All Rights Reserved Mucolytics cont Mucolytics

Copyright 2017 wolters kluwer all rights reserved

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Copyright © 2017 Wolters Kluwer • All Rights Reserved Mucolytics (cont.) Mucolytics (cont.) Pharmacokinetics Nebulization or direct instillation into the trachea Caution Acute bronchospasm, peptic ulcer, and esophageal varicies Adverse Effects GI upset Stomatitis and/or rhinorrhea Bronchospasm Rash
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Nursing Considerations for Mucolytics Nursing Considerations for Mucolytics Assess: History and Physical Exam and known allergy Presence of acute bronchospasm, peptic ulcer and esophageal varices Skin, B/P, pulse, respirations and adventitious sounds
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Prototype Mucolytics Prototype Mucolytics
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Question Question What drug enhances the output of respiratory tract fluid by reducing the adhesiveness and surface tension of the fluid, which facilitates the removal of viscous mucus? A. Guaifenesin B. Flunisolide C. Acetylcysteine D. Dextromethorphan
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 55: Drugs Acting on the Lower Respiratory Tract Chapter 55: Drugs Acting on the Lower Respiratory Tract
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Changes in the Airway With COPD Changes in the Airway With COPD
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Prevention and Treatment for COPD Prevention and Treatment for COPD Reduce environmental exposure to irritants Smoking cessation Filter allergens from the air Avoid exposure to known irritants and allergens Open the conducting airways through muscular bronchodilation Decrease the effects of inflammation on the airway lining
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Xanthines Xanthines Facilitate respiration by dilating the airways Include two categories Sympathomimetics and Anticholinergics Aminophylline (generic) Caffeine ( Caffedrine , and others) Dyphylline (generic) Theophylline (generic)
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Xanthines Xanthines Actions Direct effect on the smooth muscles of the respiratory tract , both in the bronchi and in the blood vessels Indications Symptomatic relief or prevention of bronchial asthma and for reversal of bronchospasm associated with COPD Pharmacokinetics Narrow therapeutic margin Rapidly absorbed for the GI tract Metabolized in the liver and excreted in the urine
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Xanthines (cont.) Xanthines (cont.) Contraindications GI problems, coronary disease, respiratory dysfunction, renal or hepatic disease, alcoholism, or hyperthyroidism Adverse Effects Related to theophylline levels in the blood GI upset, nausea, irritability, and tachycardia to seizure, brain damage, and even death Drug-to-Drug Interactions Many drugs interact with xanthines Nicotine increases the metabolism
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Copyright © 2017 Wolters Kluwer • All Rights Reserved
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