Describe how activation of a gs coupled receptor can

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Describe how activation of a Gs-coupled receptor can lead to the stimulation of PKA Describe the molecular features of PKA that are involved in its signaling capacity Compare and contrast the cAMP and cGMP signaling pathways Define PDE and describe their general structure Identify the 2 major PDEs in the brain List the regulatory factors controlling general PDE activity
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Four general patterns of signal transduction 1-Direct ionophore activation ion influx or efflux 2-GPCR activation indirect activation/inhibition of ionophores stimulation of second messenger systems (protein kinases and phosphatases) 3-Neurotrophic receptor activation activation of tyrosine kinase activity 4-Steroid receptor activation translocation to nucleus and activation of gene transcription
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