Lecture_4-Overview_of_signaling_cAMP

Describe how activation of a gs coupled receptor can

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Describe how activation of a Gs-coupled receptor can lead to the stimulation of PKA Describe the molecular features of PKA that are involved in its signaling capacity Compare and contrast the cAMP and cGMP signaling pathways Define PDE and describe their general structure Identify the 2 major PDEs in the brain List the regulatory factors controlling general PDE activity
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Four general patterns of signal transduction 1-Direct ionophore activation ion influx or efflux 2-GPCR activation indirect activation/inhibition of ionophores stimulation of second messenger systems (protein kinases and phosphatases) 3-Neurotrophic receptor activation activation of tyrosine kinase activity 4-Steroid receptor activation translocation to nucleus and activation of gene transcription
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Fast Synaptic Transmission Ligand-gated ion channels (LGCs) or ionotropic receptors •Typically consist of 5 subunits arranged to form a central pore •considerable heterogeneity in the subunit composition variation in function •Each subunit contains 4 hydrophobic domains that span the membrane •M2 domain lines the pore and confers ion selectivity •agonist binding induces a conformational change in the receptor that opens the pore •pore opening permits the passage of ions (Na+, K+, Ca2+ or Cl-) •passage of cations (+) depolarizes the membrane •passage of anions (-; Cl-) hyperpolarizes the membrane •Very fast signaling; miliseconds of receptor activation
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Describe how activation of a Gs coupled receptor can lead...

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