Red Blood Cell (RBC) = Erythrocyte Figure 17.7 on page 638 in the textbook reviews the life cycle of RBC’sRed blood cells (erythrocytes) are biconcave disks and this shape increases the _surface_______ _area_______ of the cell and maximizes diffusion of gases. Watch the hemoglobin animation in the course documents. What is hypoxia? What is cyanosis? RBCcounts:What is a typical RBC count for males? What is a typical RBC count for females? 2
RBC Production: After birth, RBC production occurs in the red ___ bone _____________ _ marrow ___________. The average life span of a red blood cell is __ 120 days ______________________. Control of RBC production: Hormonal Control: The total number of red blood cells remains relatively constant due to a __ negative ________________ feedback mechanism utilizing the hormone _ erythropoietin _____________________that is released from the kidneys and liver in response to the detection of low _ oxygen _______________ levels Dietary Factors Affecting Red Blood Cell Production: Vitamins _ B12 _______ and __ folic __________ acid are needed for DNA synthesis, so they are necessary for the reproduction of all body cells, especially in hematopoietic tissue. The mineral __ iron __________________________ is also needed for hemoglobin synthesis. Destruction of Red Blood Cells With age, red blood cells become increasingly fragile and are damaged by passing through _ capillaries _________________. Macrophages in the _ liver _______________ and _ spleen ________________ phagocytize damaged red blood cells. Hemoglobin from the decomposed red blood cells is converted into _ heme _______________ and __ globin ______________. What happens to the heme and iron? Heme is broken down into bilirubin and is picked up by the liver and into iron which is stored as ferritin or hemosiderin which is then bound to transferrin and released to blood from liver as needed for blood production How is physiologic jaundice in newborns related to the destruction of heme? How is it treated? phototherapy Red Blood Cell Disorders 3
What is anemia?
You've reached the end of your free preview.
Want to read all 8 pages?
- Winter '14
- red blood cells