Red Blood Cell (RBC) = Erythrocyte
Figure 17.7 on page 638 in the textbook reviews the life cycle of RBC’sRed blood cells (erythrocytes) are biconcave disks and this shape increases the _surface_______ _area_______ of the cell and maximizes diffusion of gases. Watch the hemoglobin animation in the course documents.
What is hypoxia?
What is cyanosis?
RBCcounts:What is a typical RBC count for males?
What is a typical RBC count for females?
2
RBC Production:
After birth, RBC production occurs in the red ___
bone
_____________
_
marrow
___________.
The average life span of a red blood cell is __
120 days
______________________.
Control of RBC production:
Hormonal Control:
The total number of red blood cells remains relatively constant due to a
__
negative
________________
feedback mechanism utilizing the hormone _
erythropoietin
_____________________that is released
from the kidneys and liver in
response to the detection of low _
oxygen
_______________ levels
Dietary Factors Affecting Red Blood Cell Production:
Vitamins _
B12
_______ and __
folic
__________ acid are needed for DNA synthesis, so they are
necessary
for the reproduction of all body cells, especially in hematopoietic tissue.
The mineral __
iron
__________________________ is also needed for hemoglobin synthesis.
Destruction of Red Blood Cells
With age, red blood cells become increasingly fragile and are damaged by passing through
_
capillaries
_________________.
Macrophages in the
_
liver
_______________ and _
spleen
________________
phagocytize
damaged red
blood cells.
Hemoglobin from the decomposed red blood cells is converted into _
heme
_______________ and
__
globin
______________.
What happens to the heme and iron?
Heme is broken down into bilirubin and is picked up by the
liver and into iron which is stored as ferritin or hemosiderin which is then bound to transferrin and
released to blood from liver as needed for blood production
How is physiologic jaundice in newborns related to the destruction of heme?
How is it treated?
phototherapy
Red Blood Cell Disorders
3
What is anemia?
You've reached the end of your free preview.
Want to read all 8 pages?
- Winter '14
- red blood cells
