Mania: The most common symptoms of drug-induced mania are increased activity, rapid speech, elevated mood and insomnia. Causes can include: • Hallucinogens (e.g. LSD) • CNS stimulants (e.g. amfetamines, caffeine, ephedrine, methylphenidate, phenylephrine, phenylpropanolamine, modafinil) • Antidepressants (switching from depression to mania; risk factors include prior history, family history or concurrent mood disorder, Bipolar III) • Antipsychotics (olanzapine, risperidone, quetiapine, more than the older antipsychotics). Depression: • There are few reported cases of drug-induced bipolar depression.